Altered signature of apoptotic endothelial cell-derived microvesicles predicts chronic heart failure phenotypes.

: to evaluate the associations between signatures of apoptotic endothelial cell-derived microvesicles (MVs) with phenotypes of chronic heart failure (HF). The study cohort consisted of 388 prospectively involved subjects with HF patients with predominantly reduced left ventricular ejection fraction (HFrEF), HF with preserved ejection fraction (HFpEF) and HF with mid-range ejection fraction (HFmrEF). All biomarkers were measured at baseline. The number of circulating CD31/annexin V MVs in HFrEF and HFmrEF patients was similar. The number of circulating CD144/annexin V MVs in HFrEF patients was significantly higher than HFmrEF and HFpEF. We determined that a combination of number of circulating CD31/annexin V MVs and Gal-3 was the best predictor of HFpEF and that number of circulating CD144/annexin V MVs is able to increase predictive capabilities of soluble ST2 (sST2) and Gal-3 for HFrEF. We found that the number of circulating CD31/annexin V MVs may improve a predictive capacity for conventional HF biomarkers.