de Brot S, Grau-Roma L, Stirling-Stainsby C, Dettwiler M, Guscetti F, Meier D, Scase T, Robinson B D, Gardner D, Mongan N P
School of Veterinary Medicine and Science, University of Nottingham, UK; Institute of Animal Pathology, University of Bern, Switzerland.
Institute of Animal Pathology, University of Bern, Switzerland.
J Comp Pathol. 2019 May;169:35-46. doi: 10.1016/j.jcpa.2019.04.003. Epub 2019 May 17.
Canine urothelial carcinoma (UC) is the most common type of cancer of the lower urinary tract and tends to affect elderly neutered female dogs, with a high predisposition for Scottish terriers. Tumour stroma, inflammation and necrosis are poorly characterized in canine UC and their role as prognostic factors is unknown. The aims of this study were to (1) assess histologically 381 canine UCs, with emphasis on myxoid tumour stroma, inflammation and necrosis and (2) assess possible associations between these features and the available epidemiological data as well as bladder wall muscle invasion. In 103 of 381 (27%) cases, the stroma was mixed collagenous and myxoid (fibromyxoid), which was strongly associated with invasive growth of muscle (P <0.0001). Peritumoural and intratumoural inflammation was present in 308 of 345 (89%) and 287 of 381 (75%) cases, respectively, and was mostly mild and lymphoplasmacytic. One hundred and fifteen of the 381 (30%) cases showed a variable eosinophilic inflammation and 58 of 381 (15%) presented with formations of one or several lymphoid follicles. Twenty-four percent (91 of 381) of cases had tumour necrosis, which was typically mild. In 83 of 91 (91%) cases, the necrosis was comedo-like. Moderate to severe tumour necrosis was associated with the presence of moderate to predominant fibromyxoid tumour stroma (P <0.02). The results of this study indicate that fibromyxoid stroma is common in canine UC and is a strong indicator for invasive growth of muscle, which is consistent with a poor prognosis. Based on histomorphology, tumour necrosis in canine UC is best described as comedonecrosis.
犬尿路上皮癌（UC）是下尿路最常见的癌症类型，往往影响老年绝育雌性犬，苏格兰梗犬易感性高。犬UC中的肿瘤基质、炎症和坏死特征描述不足，它们作为预后因素的作用尚不清楚。本研究的目的是：（1）对381例犬UC进行组织学评估，重点关注黏液样肿瘤基质、炎症和坏死；（2）评估这些特征与现有流行病学数据以及膀胱壁肌肉浸润之间的可能关联。在381例中的103例（27%）病例中，基质为胶原和黏液样混合（纤维黏液样），这与肌肉浸润性生长密切相关（P<0.0001）。分别在345例中的308例（89%）和381例中的287例（75%）病例中存在瘤周和瘤内炎症，且大多为轻度淋巴浆细胞性炎症。381例中的115例（30%）病例表现为不同程度的嗜酸性炎症，381例中的58例（15%）出现一个或多个淋巴滤泡形成。24%（381例中的91例）病例有肿瘤坏死，通常为轻度。在91例中的83例（91%）病例中，坏死呈粉刺样。中重度肿瘤坏死与中度至主要为纤维黏液样肿瘤基质的存在相关（P<0.02）。本研究结果表明，纤维黏液样基质在犬UC中常见，是肌肉浸润性生长的有力指标，这与预后不良一致。基于组织形态学，犬UC中的肿瘤坏死最好描述为粉刺样坏死。
