Wellcome Sanger Institute, Hinxton, Cambridge, UK.
Department of Pathology, Western General Hospital, Edinburgh, Scotland, UK.
J Comp Pathol. 2021 Jan;182:9-14. doi: 10.1016/j.jcpa.2020.11.001. Epub 2020 Dec 5.
Urothelial (transitional cell) carcinoma (UC) is the most common type of bladder cancer in humans, dogs and cats, although the incidence in cats is comparatively low. This retrospective study details the histopathological features of UC of the urinary bladder in 38 samples from 35 cats. Of the 38 samples, eight had a papillary architecture and in nine the tumour cells formed tubular or acinar structures. Tumour cell invasion of the bladder wall varied from confinement within the lamina propria or submucosa to transmural or extending to the serosa. The tumour stroma varied from sparse to abundant, with a scirrhous, myxomatous or mucinous appearance in eleven cases, three cases and one case, respectively. The degrees of tumour cell necrosis and inflammation were highly variable. We confirm that the histopathological features of bladder UC in cats have many similarities to the corresponding tumours in dogs and humans.
尿路上皮（移行细胞）癌（UC）是人类、犬和猫中最常见的膀胱癌类型，尽管猫的发病率相对较低。本回顾性研究详细描述了 35 只猫的 38 个膀胱 UC 样本的组织病理学特征。在这 38 个样本中，有 8 个具有乳头状结构，9 个肿瘤细胞形成管状或腺泡状结构。肿瘤细胞对膀胱壁的浸润从局限于固有层或黏膜下层到穿透壁层或延伸到浆膜层不等。肿瘤基质从稀疏到丰富不等，11 例呈硬癌样、黏液样或黏液样外观，3 例和 1 例分别呈黏液样外观。肿瘤细胞坏死和炎症的程度差异很大。我们证实，猫的膀胱 UC 的组织病理学特征与犬和人类的相应肿瘤有许多相似之处。
