Institut Jacques Monod, Université Paris Diderot, Paris, France; Université Paris-Diderot, Paris, France.
Trends Biochem Sci. 2019 Aug;44(8):645-647. doi: 10.1016/j.tibs.2019.04.013. Epub 2019 May 31.
A recent study assessed the impact of cell size on various cell properties. Oversized yeast cells display slow cell division, cytoplasmic dilution, and transcriptomic and proteomic alterations. It highlights commonalities between aging yeast and mammalian cells, suggesting the existence of a range of DNA content: cell volume ratio ensuring optimal function.
最近的一项研究评估了细胞大小对各种细胞特性的影响。过大的酵母细胞表现出缓慢的细胞分裂、细胞质稀释以及转录组和蛋白质组的改变。这突出了衰老酵母和哺乳动物细胞之间的共性，表明存在一系列确保最佳功能的 DNA 含量与细胞体积比。
