Robbins D S, Shirazi Y, Drysdale B E, Lieberman A, Shin H S, Shin M L
Department of Pathology, University of Maryland School of Medicine, Baltimore 21201.
J Immunol. 1987 Oct 15;139(8):2593-7.
Stimulation of rat astrocytes in vitro by calcium ionophore A23187 and/or lipopolysaccharide results in the generation of a cytotoxic factor that is functionally similar to the previously described macrophage-derived cytotoxic factor, tumor necrosis factor. Like the macrophage product, the astrocyte cytotoxic factor kills murine L 929 cell targets. In addition, it kills rat oligodendrocytes, the myelin-producing cells of the central nervous system. Human recombinant tumor necrosis factor also has cytotoxic activity directed against rat oligodendrocytes.
用钙离子载体A23187和/或脂多糖在体外刺激大鼠星形胶质细胞，会产生一种细胞毒性因子，其功能类似于先前描述的巨噬细胞衍生的细胞毒性因子——肿瘤坏死因子。与巨噬细胞产物一样，星形胶质细胞细胞毒性因子可杀死小鼠L 929细胞靶标。此外，它还能杀死大鼠少突胶质细胞，即中枢神经系统中产生髓磷脂的细胞。人重组肿瘤坏死因子也具有针对大鼠少突胶质细胞的细胞毒性活性。
