Lab of Computational Chemistry and Drug Design, State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
College of Information Engineering, Shenzhen University, Shenzhen 518060, China.
Bioinformatics. 2019 Nov 1;35(22):4824-4826. doi: 10.1093/bioinformatics/btz460.
The WD40-repeat proteins are a large family of scaffold molecules that assemble complexes in various cellular processes. Obtaining their structures is the key to understanding their interaction details. We present WDSPdb 2.0, a significantly updated resource providing accurately predicted secondary and tertiary structures and featured sites annotations. Based on an optimized pipeline, WDSPdb 2.0 contains about 600 thousand entries, an increase of 10-fold, and integrates more than 37 000 variants from sources of ClinVar, Cosmic, 1000 Genomes, ExAC, IntOGen, cBioPortal and IntAct. In addition, the web site is largely improved for visualization, exploring and data downloading.
http://www.wdspdb.com/wdsp/ or http://wu.scbb.pkusz.edu.cn/wdsp/.
Supplementary data are available at Bioinformatics online.
WD40 重复蛋白是一个大型支架分子家族,它们在各种细胞过程中组装复合物。获得它们的结构是理解其相互作用细节的关键。我们介绍了 WDSPdb 2.0,这是一个经过显著更新的资源,提供了准确预测的二级和三级结构以及特征位点注释。基于优化的流水线,WDSPdb 2.0 包含约 60 万个条目,增加了 10 倍,并整合了来自 ClinVar、Cosmic、1000 Genomes、ExAC、IntOGen、cBioPortal 和 IntAct 等来源的超过 37000 个变体。此外,该网站在可视化、探索和数据下载方面有了很大的改进。
http://www.wdspdb.com/wdsp/ 或 http://wu.scbb.pkusz.edu.cn/wdsp/。
补充数据可在 Bioinformatics 在线获得。