Bein B, Schiewe R, Renner J
Klinik für Anästhesiologie, Intensivmedizin, Notfallmedizin und Schmerztherapie, Asklepios Klinik St. Georg, Lohmühlenstr. 5, 20099, Hamburg, Deutschland.
Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Deutschland.
Anaesthesist. 2019 Aug;68(8):497-508. doi: 10.1007/s00101-019-0605-z.
In the future an increasing number of older patients with significant comorbidities will have to undergo major surgical procedures. Perioperative cardiovascular events account for many major complications and even fatalities. While perioperative myocardial infarction (PMI) is a generally well-known and recognized complication, the less severe myocardial injury after non-cardiac surgery (MINS) has not gained widespread scientific attention until recently; however, two large observational trials (VISION 1 and VISION 2) have shown a significantly increased mortality after MINS with even subtle increases in troponin T being associated with an increased risk of death. This review summarizes the current knowledge pertaining to PMI and MINS and proposes a diagnostic and therapeutic framework for optimally guiding patients at risk through the perioperative period.
未来,越来越多患有严重合并症的老年患者将不得不接受大型外科手术。围手术期心血管事件是许多主要并发症甚至死亡的原因。虽然围手术期心肌梗死(PMI)是一种广为人知且公认的并发症,但非心脏手术后较轻的心肌损伤(MINS)直到最近才受到广泛的科学关注;然而,两项大型观察性试验(VISION 1和VISION 2)表明,MINS后死亡率显著增加,即使肌钙蛋白T有轻微升高也与死亡风险增加相关。本综述总结了目前关于PMI和MINS的知识,并提出了一个诊断和治疗框架,以最佳地指导高危患者度过围手术期。