Centre for Addiction Medicine, Department of Psychiatry, National Institute of Mental Health and Neurosciences , Bengaluru , India.
Department of Psychiatry, National Institute of Mental Health and Neurosciences , Bengaluru , India.
J Dual Diagn. 2019 Jul-Sep;15(3):172-176. doi: 10.1080/15504263.2019.1619008. Epub 2019 Jun 4.
The objective of the study was to examine the correlates, phenomenology, and short-term treatment response to benzodiazepines and antipsychotics in an inpatient sample with alcohol-induced psychotic disorder, predominant hallucinations i.e., F10.52. We reviewed the charts of the patients admitted in a tertiary care addiction treatment center between 2010 and 2016 with the diagnosis of alcoholic hallucinosis. Among 6,493 patients admitted with alcohol dependence during the study period, 61 patients (0.9%) had alcoholic hallucinosis. Among them, 41 (67.2%) had alcoholic hallucinosis in the past; 26 (42.6%) had a family history of psychosis. Only auditory hallucinations were found in 46 patients (75.4%), only visual hallucinations in 3 patients (5%), and both auditory and visual hallucinations in 12 (19.7%). Thirty-four (55.7%) had delusions, which were secondary to hallucinations. Suicidality which includes suicidal ideas and attempts was noted in 12 (19.7%) patients. Fifty-three (86.9%) patients had hallucinations exclusively during alcohol withdrawal, while 8 (13.1%) had them during withdrawal as well as while consuming alcohol. At the end of six months, 13.1% of the patients had an independent psychotic disorder diagnosed. The primary mode of management was treatment with only benzodiazepines ( = 37, 60.7%) or benzodiazepines and antipsychotics ( = 24, 39.3%). The reasons for starting antipsychotics were the presence of florid psychotic symptoms (26.2%) and incomplete symptom resolution with benzodiazepines (9.8%). The median duration of response was four days, with 25th to 75th quartile range at two to seven days. Alcoholic hallucinosis is an acute short-lasting psychotic disorder which lasts for less than a week when treated. Suicidality is high in this group, which needs attention. Benzodiazepines as part of withdrawal management may be sufficient for a majority of cases. Antipsychotics may be required in selected cases. A high degree of recurrence and morbidity indicates a need to intervene early with an abstinence-oriented management goal.
本研究旨在探讨住院酒精所致精神病性障碍患者(主要为幻觉,F10.52)中苯二氮䓬类药物和抗精神病药物的相关性、表现和短期治疗反应。我们回顾了 2010 年至 2016 年期间在一家三级成瘾治疗中心住院的诊断为酒精性幻觉症患者的病历。在研究期间,6493 例酒精依赖患者中,有 61 例(0.9%)患有酒精性幻觉症。其中,41 例(67.2%)有既往酒精性幻觉症病史;26 例(42.6%)有精神病家族史。仅 46 例(75.4%)存在听觉幻觉,3 例(5%)存在视觉幻觉,12 例(19.7%)存在听觉和视觉幻觉。34 例(55.7%)有妄想,继发于幻觉。12 例(19.7%)患者有自杀意念和企图。53 例(86.9%)患者仅在酒精戒断时出现幻觉,8 例(13.1%)患者在戒断时以及饮酒时出现幻觉。在六个月结束时,13.1%的患者被诊断为独立的精神病性障碍。主要的治疗模式是仅使用苯二氮䓬类药物( = 37,60.7%)或苯二氮䓬类药物和抗精神病药物( = 24,39.3%)。开始使用抗精神病药物的原因是存在明显的精神病症状(26.2%)和苯二氮䓬类药物治疗不完全(9.8%)。反应的中位持续时间为 4 天,25%至 75%的四分位距为 2 至 7 天。酒精性幻觉症是一种急性短暂的精神病性障碍,治疗后持续时间不到一周。该组自杀率较高,需要引起重视。苯二氮䓬类药物作为戒断管理的一部分,可能对大多数病例有效。在某些情况下可能需要使用抗精神病药物。高复发率和发病率表明需要早期干预,以达到以戒断为导向的管理目标。