18F-PSMA 1007 脑 PET/CT 成像在胶质瘤复发中的应用。

18F-PSMA 1007 Brain PET/CT Imaging in Glioma Recurrence.

机构信息

From the Jaber Alahmad Centre for Molecular Imaging, Shuwaikh, Kuwait.

St Gregorios International Cancer Care Centre, Parumala, Kerala, India.

出版信息

Clin Nucl Med. 2020 Jan;45(1):e61-e62. doi: 10.1097/RLU.0000000000002668.

DOI:10.1097/RLU.0000000000002668

PMID:31162269

Abstract

A 64-year-old man with a known case of right parietal lobe glioblastoma multiforme operated on in August 2018 was referred for F-FDG PET/CT with a clinical suspicion of recurrence. He underwent F-FDG and F-PSMA 1007 scans. Both the scans showed intense tracer uptake in right parietal lobe lesion, which concurred with MRI findings of recurrent disease and was later proven on histopathologic examination as recurrence. Our case highlights the feasibility of F-PSMA 1007 PET/CT imaging of suspected glioblastoma recurrence. Considering its similarity to PSMA-617, it may be used as a surrogate imaging tracer for potential theranostic application using alpha or beta emitters.

摘要

一位 64 岁男性，2018 年 8 月因右侧顶叶多形性胶质母细胞瘤接受手术治疗，因疑似复发而进行 F-FDG PET/CT 检查。他接受了 F-FDG 和 F-PSMA 1007 扫描。两次扫描均显示右侧顶叶病变摄取了强烈的示踪剂，与 MRI 发现的复发病灶一致，随后在组织病理学检查中证实为复发。本病例突出了 F-PSMA 1007 PET/CT 成像在疑似胶质母细胞瘤复发中的可行性。鉴于其与 PSMA-617 的相似性，它可能被用作使用α或β发射体进行潜在治疗应用的替代成像示踪剂。