Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing, P. R. China.
Jiangsu Key Laboratory of Research and Development in Marine Bio-resource Pharmaceutics, Nanjing University of Chinese Medicine, Nanjing, P. R. China.
Electrophoresis. 2019 Oct;40(20):2759-2766. doi: 10.1002/elps.201900078. Epub 2019 Jun 13.
Goat horn (Caprae Hircus Cornu, GH) has been used as a substitute for Saiga antelope horn (Saigae Tataricae Cornu, SAH) in the clinic and the pharmaceutical industry. In the present study, peptides released from SAH and GH under simulated gastric and intestinal digestion were identified. The results showed that most of the peptides released from SAH and GH under simulated gastrointestinal digestion were hydrophilic, and over 75% of the peptides from keratins (KRTs) were hydrophilic. In total, over 58% of the identified peptides were released from KRTs, and were from the four main regions of KRTs. The peptide features and the peptide release profiles from KRTs in SAH and GH were similar, which may provide a method for the identification of sustainable alternatives to replace the threatened SAH, and provide further evidence of the feasibility of using GH as a replacement for SAH based on their peptidomic analysis.
羊角（Caprae Hircus Cornu，GH）已在临床上和制药行业中被用作赛加羚羊角（Saigae Tataricae Cornu，SAH）的替代品。在本研究中，鉴定了 SAH 和 GH 在模拟胃和肠消化下释放的肽。结果表明，SAH 和 GH 在模拟胃肠消化下释放的大多数肽是亲水性的，超过 75%的角蛋白（KRTs）肽是亲水性的。总共，超过 58%的鉴定肽是从 KRTs 中释放出来的，并且来自 KRTs 的四个主要区域。SAH 和 GH 中 KRTs 释放的肽特征和肽释放谱相似，这可能为识别可持续替代品提供了一种方法，以替代受到威胁的 SAH，并为基于肽组学分析使用 GH 替代 SAH 的可行性提供了进一步的证据。
