Tomić R, Bergman B
Department of Urology, University of Umeå, Sweden.
J Urol. 1987 Oct;138(4):801-3. doi: 10.1016/s0022-5347(17)43379-9.
Serum concentrations of testosterone, luteinizing hormone and follicle-stimulating hormone were measured before, and at 1, 12 and 24 months after cessation of long-term estrogen treatment (mean 8.7 years, range 4.3 to 13.1 years) in 14 patients with prostatic carcinoma but without metastases. In addition, the same hormones were measured before and up to 24 months after orchiectomy in 14 age-matched, previously untreated patients also without metastases. In long-term estrogen-treated patients serum concentrations of testosterone found at 1, 12 and 24 months after cessation of estrogen did not differ significantly either from the value before estrogen withdrawal or from the corresponding values found in age-matched patients after orchiectomy. The concentrations of luteinizing and follicle-stimulating hormones increased significantly in the estrogen-treated patients after cessation of estrogen and in the age-matched patients after orchiectomy. However, luteinizing and follicle-stimulating hormones were significantly lower in the patients after estrogen treatment than in the age-matched patients after orchiectomy. During the study period only 1 patient from the estrogen-treated group had clinical progression and he died of prostatic carcinoma. We conclude that long-term estrogen treatment causes impairment of Leydig cell function in patients with prostatic carcinoma and, as a result, the serum testosterone concentrations do not increase when that treatment is discontinued.
对14例无转移的前列腺癌患者在长期雌激素治疗停止前以及停止治疗后1个月、12个月和24个月（平均8.7年，范围4.3至13.1年）测定血清睾酮、黄体生成素和卵泡刺激素浓度。此外，对14例年龄匹配、未经治疗且同样无转移的患者在睾丸切除术前及术后长达24个月测定相同的激素。在长期接受雌激素治疗的患者中，雌激素停止治疗后1个月、12个月和24个月时测得的血清睾酮浓度与雌激素撤药前的值以及年龄匹配的患者睾丸切除术后的相应值相比，均无显著差异。雌激素治疗的患者在停止雌激素治疗后以及年龄匹配的患者在睾丸切除术后，黄体生成素和卵泡刺激素的浓度均显著升高。然而，雌激素治疗后的患者中黄体生成素和卵泡刺激素显著低于年龄匹配的睾丸切除术后患者。在研究期间，雌激素治疗组仅有1例患者出现临床进展并死于前列腺癌。我们得出结论，长期雌激素治疗会导致前列腺癌患者的睾丸间质细胞功能受损，因此，停止该治疗后血清睾酮浓度不会升高。
