Demidko Yu L, Rudenko V I, Grigoryan V A, Enikeev M E, Allenov S N, Kasiteridi I G, Ujegov T A, Amosov A V
Clinic of Urology and Male Reproductive Health, LDO 4 UKB 2 FGAOU VO VO I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia, Moscow, Russia.
Urologiia. 2019 Jun(2):15-20.
The drug Canephron N is a combination of extracts of centaury, lovage and rosemary. Moderate antispasmoic, anti-inflammatory, antioxidant, diuretic and antimicrobial effects are of great interest for urological practice. The optimal combination of components that were made of herbal medicine allows to use their synergistic effect for prevention of recurrence of urinary stone disease. The experience of using the drug Canephron in clinical practice is of great interest.
to clarify the clinical efficiency of Canephron N in patients with urinary stone disease after surgical treatment and to evaluate the changes in diuresis and calcium excretion.
The results of using the drug Canephron after surgical treatment of urinary stone disease are provided. The changes in diuresis and calcium excretion in 75 patients undergone surgical treatment of urinary stone disease were studied. Patients after ureteroscopy, percutaneous nephrolithotomy and extracorporeal shock-wave lithotripsy were prescribed treatment to prevent stone formation including herbal drug Canephron N.
At baseline, there was negative correlation between 24-hours diuresis and calcium excretion in all groups. During follow-up, a positive correlation between 24-hours diuresis and calcium excretion was found in patients receiving Canephron N and other types of treatment. The average follow-up was 390 days. During this period, recurrence was noted in 1 patient receiving Canephron, 4 patients in patients who took other drugs and in 5 patients who didnt receive any treatment.
Risk factors of stone formation persist after surgical treatment of urinary stone disease. This is reflected in a negative correlation between 24-hour diuresis and calcium excretion. During treatment, a positive correlation between diuresis and calcium excretion was noted in patients with urinary stone disease. The use of drugs that affect stone formation as well as herbal medicine Canephron N allow to obtain comparable ratio of diuresis and calcium excretion.
Canephron N 药物是由百金花、欧当归和迷迭香提取物组成的复方制剂。其适度的解痉、抗炎、抗氧化、利尿和抗菌作用对泌尿外科临床实践具有重要意义。由草药制成的各成分的最佳组合可利用其协同作用预防尿路结石病复发。在临床实践中使用 Canephron 药物的经验备受关注。
明确 Canephron N 对尿路结石病患者手术治疗后的临床疗效，并评估利尿和钙排泄的变化。
提供了尿路结石病手术治疗后使用 Canephron 药物的结果。研究了 75 例接受尿路结石病手术治疗患者的利尿和钙排泄变化。对输尿管镜检查、经皮肾镜取石术和体外冲击波碎石术后的患者进行了预防结石形成的治疗，包括使用草药 Canephron N。
基线时，所有组的 24 小时尿量与钙排泄之间呈负相关。随访期间，接受 Canephron N 和其他类型治疗的患者中，24 小时尿量与钙排泄之间呈正相关。平均随访时间为 390 天。在此期间，接受 Canephron 治疗的患者中有 1 例复发，服用其他药物的患者中有 4 例复发，未接受任何治疗的患者中有 5 例复发。
尿路结石病手术治疗后结石形成的危险因素依然存在。这表现为 24 小时尿量与钙排泄之间呈负相关。治疗期间，尿路结石病患者的尿量与钙排泄之间呈正相关。使用影响结石形成的药物以及草药 Canephron N 可使尿量与钙排泄达到可比的比例。
