Laboratory of Neurobiology, Centro de Investigación Príncipe Felipe, Valencia, Spain.
Fundación Investigación Hospital Clínico, Instituto de Investigación Sanitaria (INCLIVA), Valencia, Spain.
FASEB J. 2019 Sep;33(9):9913-9928. doi: 10.1096/fj.201900230RR. Epub 2019 Jun 4.
Activated microglia and increased brain IL-1β play a main role in cognitive impairment in much pathology. We studied the role of IL-1β in neuroinflammation-induced impairment of the following different types of learning and memory: novel object recognition (NOR), novel object location (NOL), spatial learning, reference memory (RM), and working memory (WM). All these processes are impaired in hyperammonemic rats. We assessed which of these types of learning and memory are restored by blocking the IL-1 receptor in hyperammonemic rats and the possible mechanisms involved. Blocking the IL-1 receptor reversed microglial activation in the hippocampus, perirhinal cortex, and prefrontal cortex but not in the postrhinal cortex. This was associated with the restoration of NOR and WM but not of tasks involving a spatial component (NOL and RM). This suggests that IL-1β would be involved in neuroinflammation-induced nonspatial memory impairment, whereas spatial memory impairment would be IL-1β-independent and would be mediated by other proinflammatory factors.-Taoro-González, L., Cabrera-Pastor, A., Sancho-Alonso, M., Arenas, Y. M., Meseguer-Estornell, F., Balzano, T., ElMlili, N., Felipo, V. Differential role of interleukin-1β in neuroinflammation-induced impairment of spatial and nonspatial memory in hyperammonemic rats.
活化的小胶质细胞和大脑中白细胞介素-1β的增加在许多病理中起主要作用于认知障碍。我们研究了白细胞介素-1β在神经炎症引起的以下不同类型的学习和记忆损伤中的作用：新物体识别（NOR）、新物体位置（NOL）、空间学习、参考记忆（RM）和工作记忆（WM）。所有这些过程在高氨血症大鼠中都受到损害。我们评估了阻断高氨血症大鼠中的白细胞介素-1受体后哪些类型的学习和记忆得到恢复，以及涉及的可能机制。阻断白细胞介素-1受体可逆转海马体、边缘区和前额叶皮质中的小胶质细胞活化，但在后边缘区没有。这与 NOR 和 WM 的恢复有关，但与涉及空间成分的任务（NOL 和 RM）无关。这表明白细胞介素-1β可能参与神经炎症引起的非空间记忆损伤，而空间记忆损伤与白细胞介素-1β无关，而是由其他促炎因子介导的。
