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对比光学相干断层扫描血管造影与荧光素血管造影在视网膜静脉阻塞患者中的中心凹无血管区。

Comparison of foveal avascular zone between optical coherence tomography angiography and fluorescein angiography in patients with retinal vein occlusion.

机构信息

Department of Ophthalmology, Ulm University, Ulm, Germany.

Ulm University, Ulm, Germany.

出版信息

PLoS One. 2019 Jun 4;14(6):e0217849. doi: 10.1371/journal.pone.0217849. eCollection 2019.

DOI:10.1371/journal.pone.0217849
PMID:31163058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6548381/
Abstract

OBJECTIVE

To compare area of foveal avascular zone (FAZ) in different retinal vascular layers in optical coherence tomography angiography (OCTA) and fluorescein angiography (FA) in patients with retinal vein occlusion (RVO).

DESIGN AND METHODS

Prospective cross-sectional comparative study in 47 eyes of 47 patients. FA was recorded with the Zeiss FF450plusIR camera and OCTA was obtained with the Zeiss Cirrus 5000 equipped with the AngioPlex module. Area of FAZ was graded by two independent investigators and calculated with Adobe Photoshop. Analysis for the total study population as well as subgroup analysis for branch retinal vein occlusion (BRVO), central retinal vein occlusion (CRVO) and patients with and without macular edema (ME) was performed.

RESULTS

For all patients, FAZ was 0.449 mm2 in FA, 0.496 mm2 in OCTA superficial capillary layer (SCL) and 3.168 in OCTA deep capillary layer (DCL). In patients without ME FAZ was 0.288 mm2 in FA, 0.342 mm2 in OCTA SCL and 1.384 mm2 in OCTA DCL. FAZ area measurement in patients with ME revealed 0.482 mm2 in FA, 0.527 mm2 in OCTA SCL and 3.554 mm2 in OCTA DCL.

CONCLUSIONS

Especially the SCL of OCTA shows a good agreement to FA in measurement of FAZ in all patients with low limits of variation in patients without ME. There were no considerable differences in BRVO and CRVO. OCTA could replace FA in FAZ area measurement in patients with RVO, especially in those without ME, achieving similar measurements whilst being non-invasive.

摘要

目的

比较视网膜静脉阻塞（RVO）患者光学相干断层扫描血管造影（OCTA）和荧光素血管造影（FA）不同视网膜血管层中黄斑中心凹无血管区（FAZ）的面积。

设计和方法

对 47 例 47 只眼进行前瞻性横断面对照研究。使用蔡司 FF450plusIR 相机记录 FA，使用蔡司 Cirrus 5000 配备 AngioPlex 模块获得 OCTA。由两名独立观察者对 FAZ 面积进行分级，并使用 Adobe Photoshop 进行计算。对总研究人群以及分支视网膜静脉阻塞（BRVO）、中央视网膜静脉阻塞（CRVO）、有和无黄斑水肿（ME）的患者进行亚组分析。

结果

所有患者的 FAZ 在 FA 中为 0.449mm2，在 OCTA 浅层毛细血管层（SCL）中为 0.496mm2，在 OCTA 深层毛细血管层（DCL）中为 3.168mm2。在无 ME 的患者中，FAZ 在 FA 中为 0.288mm2，在 OCTA SCL 中为 0.342mm2，在 OCTA DCL 中为 1.384mm2。在有 ME 的患者中，FAZ 在 FA 中为 0.482mm2，在 OCTA SCL 中为 0.527mm2，在 OCTA DCL 中为 3.554mm2。

结论

特别是在无 ME 的患者中，OCTA 的 SCL 在 FAZ 测量方面与 FA 具有良好的一致性，且变异度较低。BRVO 和 CRVO 之间无明显差异。OCTA 可替代 FA 测量 RVO 患者的 FAZ 面积，尤其是在无 ME 的患者中，实现了类似的测量，同时具有非侵入性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b5/6548381/9c95a9ff51e6/pone.0217849.g008.jpg
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2
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3
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