Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
PLoS One. 2019 Jun 4;14(6):e0217924. doi: 10.1371/journal.pone.0217924. eCollection 2019.
We evaluated whether the pupillary light reflex is altered in benign essential blepharospasm patients. Twenty-three patients with benign essential blepharospasm, 47 with reflex blepharospasm, and 29 dry eye disease controls were included. Pupillary light reflex-related parameters were measured under mesopic (10 lux) and photopic illuminance (200 lux) using an infrared pupillometer. Additionally, we assessed photophobia grade, eyelid function, and dry eye disease-related parameters. There were no differences in age, sex predominance, or dry eye disease-related parameters among the three groups, or in photophobia grade and eyelid function between benign essential blepharospasm and reflex groups. Constriction velocity and maximum constriction velocity in the mesopic condition were significantly greater in the benign essential blepharospasm group (3.26 ± 0.56 and 5.27 ± 0.90 mm/s) than in reflex (2.86 ± 0.62 and 4.59 ± 1.00 mm/s) or dry eye disease groups (2.96 ± 0.46 and 4.72 ± 0.67 mm/s). Constriction velocity and maximum constriction velocity in the mesopic condition positively correlated with photophobia grade (r = 0.525 and 0.617, P = 0.025 and 0.006) in the benign essential blepharospasm group. Pupillary light reflex may be related to the pathophysiology of benign essential blepharospasm with photophobia. Further studies are required to reveal connections among pupillary light reflex, photophobia, and focal dystonia in benign essential blepharospasm patients with photophobia.
我们评估了瞳孔对光反射在良性特发性眼睑痉挛患者中是否发生改变。纳入了 23 例良性特发性眼睑痉挛患者、47 例反射性眼睑痉挛患者和 29 例干眼症对照组。在中光（10 勒克斯）和高光（200 勒克斯）下使用红外瞳孔计测量瞳孔对光反射相关参数。此外，我们评估了畏光程度、眼睑功能和干眼症相关参数。三组患者在年龄、性别优势或干眼症相关参数方面，以及在良性特发性眼睑痉挛和反射性组之间的畏光程度和眼睑功能方面均无差异。在中光条件下，良性特发性眼睑痉挛组的收缩速度和最大收缩速度（分别为 3.26±0.56 和 5.27±0.90mm/s）明显大于反射组（分别为 2.86±0.62 和 4.59±1.00mm/s）或干眼症组（分别为 2.96±0.46 和 4.72±0.67mm/s）。在良性特发性眼睑痉挛组中，中光条件下的收缩速度和最大收缩速度与畏光程度呈正相关（r=0.525 和 0.617，P=0.025 和 0.006）。瞳孔对光反射可能与伴畏光的良性特发性眼睑痉挛的病理生理学有关。需要进一步的研究来揭示伴畏光的良性特发性眼睑痉挛患者中瞳孔对光反射、畏光和局灶性肌张力障碍之间的联系。
