Department of Neurosciences, Institute of Health Sciences, Dokuz Eylul University, Izmir 35340, Turkey.
Department of Neurosciences, Institute of Health Sciences, Dokuz Eylul University, Izmir 35340, Turkey; Department of Psychology, Faculty of Letters, Dokuz Eylul University, Izmir 35160, Turkey; Atlantic Fellow for Equity in Brain Health at the Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.
Clin Neurophysiol. 2019 Aug;130(8):1208-1217. doi: 10.1016/j.clinph.2019.04.314. Epub 2019 May 4.
Functional and structural brain alterations of cognitively normal Parkinson's disease (PD-CN) and Parkinson's disease mild cognitive impairment (PD-MCI) patients were investigated using event-related potentials (ERP) P300 and volumetric magnetic resonance imaging (MRI) parameters.
Twenty three patients with PD-CN, 21 with PD-MCI, and 23 demographically-matched healthy controls were included. EEGs were recorded using a visual oddball task and mean amplitude and peak latency values of P300 were measured. Gray matter volumes (GMV) of thalamus, caudate, putamen, globus pallidus, hippocampus, amygdala and nucleus accumbens were obtained using FMRIB Integrated Registration and Segmentation Tool. Correlations among P300, subcortical GMV and cognitive performances were assessed.
PD-CN patients demonstrated reduced P300 amplitudes compared to healthy controls. PD-MCI patients had lower P300 amplitudes than both PD-CN patients and controls and reduced volumes of the putamen compared to controls. Both putamen volumes and P300 amplitudes showed moderate associations with executive functions.
Our findings support that P300 amplitude may be a useful marker for the detection of preclinical changes before the appearance of cognitive and structural deterioration in PD, as shown by decreased frontal P300 amplitudes in PD-CN. The reduction further spread to centro-parietal areas in PD-MCI patients, which was accompanied by lower putamen volumes.
This study is the first to report on changes in ERP P300 amplitude and subcortical volume in well-matched samples of PD-CN, PD-MCI and healthy controls.
使用事件相关电位（ERP）P300 和容积磁共振成像（MRI）参数研究认知正常帕金森病（PD-CN）和帕金森病轻度认知障碍（PD-MCI）患者的大脑功能和结构改变。
纳入 23 例 PD-CN 患者、21 例 PD-MCI 患者和 23 名年龄匹配的健康对照者。使用视觉Oddball 任务记录 EEG，并测量 P300 的平均振幅和峰值潜伏期值。使用 FMRIB 整合注册和分割工具获取丘脑、尾状核、壳核、苍白球、海马体、杏仁核和伏隔核的灰质体积（GMV）。评估 P300、皮质下 GMV 和认知表现之间的相关性。
与健康对照组相比，PD-CN 患者的 P300 振幅降低。PD-MCI 患者的 P300 振幅低于 PD-CN 患者和对照组，且与对照组相比，壳核体积减小。壳核体积和 P300 振幅均与执行功能呈中度相关。
我们的研究结果支持 P300 振幅可能是在 PD 出现认知和结构恶化之前检测临床前变化的有用标志物，因为 PD-CN 患者的额叶 P300 振幅降低。在 PD-MCI 患者中，这种减少进一步扩散到中央顶叶区域，同时伴有壳核体积减小。
这是第一项在认知正常的 PD-CN、PD-MCI 和健康对照组的匹配样本中报告 ERP P300 振幅和皮质下体积变化的研究。
