Department of Neurology, İzmir University of Economics, Medical Point Hospital, İzmir, Turkiye.
Department of Neuroscience, Institute of Health Sciences, Dokuz Eylül University, İzmir, Turkiye.
Turk J Med Sci. 2024 Jan 5;54(4):688-699. doi: 10.55730/1300-0144.5838. eCollection 2024.
BACKGROUND/AIM: In this study, besides the evaluation of gray and white matter changes in cognitively normal Parkinson's disease (PD-CN) patients with volumetric magnetic resonance imaging (MRI) parameters, it was tried to show that some neuropsychological tests may be impaired in PD-CN patients.
Twenty-six PD-CN patients and 26 healthy elderly (HC) participants were included in the current study. Global cognitive status was assessed using the mini-mental state examination (MMSE), and the Montreal cognitive assessment scale (MoCA). Attention and executive functions were evaluated using the Wechsler memory scale-revised (WMS-R) digit span test and trail making test (TMT) part A and part B, the Stroop test, semantic and phonemic fluency tests, and clock drawing test. Magnetic resonance imaging (MRI) was acquired according to the Alzheimer's disease neuroimaging initiative (ADNI) protocol.
There were no significant differences among groups regarding age, sex, handedness, and years of education. In the comparison of the PD-CN group and the HC group, there was a statistical decrease in the total animal scores, lexical fluency, TMT part A and TMT part B scores in the PD-CN group. Subcortical gray matter volumes (GMV) were significantly lower in PD-CN patients. The PD-CN group had a significantly reduced total volume of right putamen and left angular gyrus compared to that in the HC group. We observed that putamen and angular gyrus volumes were lower in PD-CN patients. On the other hand, TMT part B may be a useful pretest in detecting the conversion of mild cognitive impairment in PD.
Significant MRI volumetric measurements and neuropsychological test batteries can be helpful in the clinical follow-up in PD-CN patients.
背景/目的：在这项研究中，除了使用容积磁共振成像（MRI）参数评估认知正常的帕金森病（PD-CN）患者的灰质和白质变化外，还试图表明一些神经心理学测试可能在 PD-CN 患者中受损。
本研究纳入了 26 例 PD-CN 患者和 26 名健康老年人（HC）作为研究对象。采用简易精神状态检查（MMSE）和蒙特利尔认知评估量表（MoCA）评估总体认知状态。采用韦氏记忆量表修订版（WMS-R）数字跨度测试和连线测试（TMT）A 部分和 B 部分、斯特鲁普测试、语义和语音流畅性测试以及钟表绘制测试评估注意力和执行功能。磁共振成像（MRI）按照阿尔茨海默病神经影像学倡议（ADNI）协议采集。
三组在年龄、性别、利手和受教育年限方面无显著差异。在 PD-CN 组和 HC 组的比较中，PD-CN 组的总动物评分、词汇流畅性、TMT A 部分和 TMT B 部分评分显著降低。PD-CN 患者的皮质下灰质体积（GMV）显著降低。与 HC 组相比，PD-CN 患者右侧壳核和左侧角回的总体积明显减少。我们观察到 PD-CN 患者的壳核和角回体积较小。另一方面，TMT B 部分可能是检测 PD 患者轻度认知障碍转化的有用预测试。
显著的 MRI 容积测量和神经心理学测试组合有助于对 PD-CN 患者进行临床随访。
