遗传证据表明转化生长因子-β在特应性表型中的作用。
Genetic evidence for the role of transforming growth factor-β in atopic phenotypes.
机构信息
Laboratory of Allergic Diseases, National Institutes of Allergy and Infectious Diseases, Bethesda, MD, USA.
Laboratory of Allergic Diseases, National Institutes of Allergy and Infectious Diseases, Bethesda, MD, USA.
出版信息
Curr Opin Immunol. 2019 Oct;60:54-62. doi: 10.1016/j.coi.2019.05.002. Epub 2019 Jun 1.
Abstract
New evidence in humans and mice supports a role for transforming growth factor-β (TGF-β) in the initiation and effector phases of allergic disease, as well as in consequent tissue dysfunction. This pleiotropic cytokine can affect T cell activation and differentiation and B cell immunoglobulin class switching following initial encounter with an allergen. TGF-β can also act on mast cells during an acute allergic episode to modulate the strength of the response, in addition to driving tissue remodeling following damage caused by an allergic attack. Accordingly, genetic disorders leading to altered TGF-β signaling can result in increased rates of allergic disease.
摘要
新的人类和小鼠证据支持转化生长因子-β（TGF-β）在过敏疾病的起始和效应阶段以及随后的组织功能障碍中发挥作用。这种多功能细胞因子可以影响初始接触过敏原后的 T 细胞激活和分化以及 B 细胞免疫球蛋白类转换。TGF-β在急性过敏发作期间还可以作用于肥大细胞，调节反应强度，此外还可以在过敏攻击引起的损伤后驱动组织重塑。因此，导致 TGF-β信号改变的遗传疾病可导致过敏疾病的发生率增加。
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