Benaroya Research Institute at Virginia Mason, Seattle, Wash.
Benaroya Research Institute at Virginia Mason, Seattle, Wash; Department of Medicine, University of Washington, Seattle, Wash.
J Allergy Clin Immunol. 2017 Sep;140(3):854-857.e6. doi: 10.1016/j.jaci.2017.02.028. Epub 2017 Mar 23.
Cow’s milk allergy (CMA) is increasing in prevalence, affecting approximately 4% of children. Cow’s milk (CM) is a common cause of fatal/ near fatal anaphylactic reactions. Understanding of CM-specific CD4+ T-cells responses to milk allergens should help elucidate the pathological mechanisms of persistent CMA. Milk allergen epitopes specific T-cells were examined in CMA subjects. Frequencies and phenotypes of these T-cells were found to be different between older and younger subjects.
牛奶过敏(CMA)的患病率正在增加,约影响 4%的儿童。牛奶(CM)是导致致命/近乎致命过敏反应的常见原因。了解 CM 特异性 CD4+T 细胞对牛奶过敏原的反应应有助于阐明持续性 CMA 的病理机制。在 CMA 患者中检测到了牛奶过敏原表位特异性 T 细胞。研究发现,老年和年轻患者的这些 T 细胞的频率和表型存在差异。