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血清维生素D、甲状旁腺激素及骨密度与良性阵发性位置性眩晕的相关性

[The correlations between serum vitamin D, parathyroid hormone, and bone mineral density with benign paroxysmal positional vertigo].

作者信息

Zhang Z Y, Tian S F, Li H, Cao X W, Song Y

机构信息

Department of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Jun;33(6):504-507. doi: 10.13201/j.issn.1001-1781.2019.06.007.

Abstract

To detect serum 25-hydroxyvitamin D[25-(OH)₂-VitD₃], parathyroid hormone (PTH), and bone mineral density in patients with benign paroxysmal positional vertigo (BPPV), and to analyze their correlations with BPPV. Fifty cases of BPPV were selected as the study group, 50 healthy persons were selected as control group. Chemiluminescence assay was used to detect serum VD level, chemiluminescence immunoassay was used to detect serum PTH level, dual energy X-ray absorptiometry was used to detect bone mineral density (BMD) and T value of lumbar vertebrae 1 to lumbar vertebrae 4 in two groups. The serum 25-(OH)₂-VitD₃ level in the study group was significantly lower than that in the control group (<0.05); the serum PTH level of the study group was significantly higher than that of the control group (<0.05); there was no significant difference in T value between male BPPV patients and female BPPV patients younger than 48 years old with the control group (>0.05), T value of female BPPV patients older than 48 years old was significantly lower than that of the control group (<0.05). Logistic regression analysis showed that the decrease of serum 25-(OH)₂-VitD₃ level, the increase of PTH level, and the decrease of bone mineral density were risk factors for BPPV. The level of serum 25-(OH)₂-VitD₃ is decreased in BPPV patients, PTH level is increased and bone mineral density is decreased, they are risk factors for BPPV.

摘要

检测良性阵发性位置性眩晕(BPPV)患者血清25-羟维生素D[25-(OH)₂-VitD₃]、甲状旁腺激素(PTH)及骨密度,并分析其与BPPV的相关性。选取50例BPPV患者作为研究组,50例健康者作为对照组。采用化学发光法检测血清维生素D水平,化学发光免疫分析法检测血清PTH水平,双能X线吸收法检测两组第1至第4腰椎的骨密度(BMD)及T值。研究组血清25-(OH)₂-VitD₃水平显著低于对照组(<0.05);研究组血清PTH水平显著高于对照组(<0.05);48岁以下男性BPPV患者和女性BPPV患者的T值与对照组比较差异无统计学意义(>0.05),48岁以上女性BPPV患者的T值显著低于对照组(<0.05)。Logistic回归分析显示,血清25-(OH)₂-VitD₃水平降低、PTH水平升高及骨密度降低是BPPV的危险因素。BPPV患者血清25-(OH)₂-VitD₃水平降低、PTH水平升高及骨密度降低,它们是BPPV的危险因素。

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