Department of Otorhinolaryngology, Erzincan University Medical Faculty, Erzincan, Turkey.
Department of Medical Biochemistry, Erzincan University Medical Faculty, Erzincan, Turkey.
Ear Nose Throat J. 2021 Nov;100(9):643-646. doi: 10.1177/0145561321989451. Epub 2021 Jan 25.
Benign paroxysmal positional vertigo (BPPV) is characterized by recurrent attacks of vertigo caused by head movements. It occurs as a result of otoconia falling into the semicircular canal. Calcium and 25 hydroxyvitamin D [25(OH)D] metabolism in the inner ear play an important role in otoconia formation and degeneration. Our aim in this study was to investigate the relationship between 25(OH)D levels and BPPV.
This retrospective, case-controlled study included 52 patients with posterior canal BPPV and 52 controls aged 18 to 80 years. Age, sex, serum calcium, corrected calcium, and 25(OH)D levels of the BPPV and control group were compared.
Twenty-three of the patients were male (44.2%) and 29 were female (55.8%). The average age was 55.6 years. The 25(OH)D level was 15.3 ng/mL in the BPPV group and 20.2 ng/mL in controls. There was no significant difference in 25(OH)D and albumin-corrected calcium values ( = .394; = .084, respectively). In 80.7% of the BPPV group and 61.5% of the controls, 25(OH)D levels were 20 ng/mL and below. 25 hydroxyvitamin D deficiency was found statistically significantly more frequently in patients with BPPV ( = .030).
In our study, serum 25(OH)D levels were found to be lower in patients with BPPV, and the rate of vitamin D deficiency was higher in these patients. Based on these results, it is recommended to examine the 25(OH)D levels of patients with BPPV at the time of diagnosis.
良性阵发性位置性眩晕（BPPV）的特征是由头部运动引起的复发性眩晕发作。它是由于耳石落入半规管引起的。内耳的钙和 25 羟维生素 D [25(OH)D]代谢在耳石形成和退化中起着重要作用。我们在这项研究中的目的是研究 25(OH)D 水平与 BPPV 之间的关系。
这是一项回顾性病例对照研究，纳入了 52 例后半规管 BPPV 患者和 52 名年龄在 18 至 80 岁之间的对照组。比较了 BPPV 组和对照组的年龄、性别、血清钙、校正钙和 25(OH)D 水平。
患者中有 23 例为男性（44.2%），29 例为女性（55.8%）。平均年龄为 55.6 岁。BPPV 组的 25(OH)D 水平为 15.3ng/mL，对照组为 20.2ng/mL。25(OH)D 和白蛋白校正钙值无显著差异（ =.394； =.084）。在 80.7%的 BPPV 组和 61.5%的对照组中，25(OH)D 水平低于 20ng/mL。BPPV 患者的 25 羟维生素 D 缺乏症发生率显著高于对照组（ =.030）。
在我们的研究中，发现 BPPV 患者的血清 25(OH)D 水平较低，这些患者的维生素 D 缺乏症发生率较高。基于这些结果，建议在诊断 BPPV 时检查患者的 25(OH)D 水平。
