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具有氧化纳米纤维素和明胶的各向异性生物支架的 3D 打印算法。

3D printing algorithm of anisotropic biological scaffold with oxidized nanocellulose and gelatin.

机构信息

a College of Animal Science and Technology , Yangzhou University , Yangzhou , China.

b Yangzhou Polytechnic Institute , Yangzhou , China.

出版信息

J Biomater Sci Polym Ed. 2019 Oct;30(14):1260-1275. doi: 10.1080/09205063.2019.1627651. Epub 2019 Jun 17.

DOI:10.1080/09205063.2019.1627651
PMID:31164052
Abstract

Tissue scaffolds need to have anisotropic mechanical properties and a porous structure to meet the needs of different tissues and organs. This report presents results of a study on an especially-designed 3D printing method with oxidized nanocellulose and gelatin, analyzes the servo principle of pneumatic condensing extrusion 3D printer, and proposes a hexagonal algorithm. For the purpose of this study, a printing process file was written by G code, physical and mechanical performance of the 3D scaffolds was evaluated with Solidworks simulation, the porous structure and pressure-pull performance of the printed 3D scaffolds was observed by SEM, and experiments were conducted to measure their bio-compatibility. The study draws the conclusion that scaffolds thus printed have a highly porous structure and anisotropic mechanical properties.

摘要

组织支架需要具有各向异性的机械性能和多孔结构,以满足不同组织和器官的需求。本报告介绍了一种特别设计的基于氧化纳米纤维素和明胶的 3D 打印方法的研究结果,分析了气动冷凝挤压 3D 打印机的伺服原理,并提出了一种六边形算法。为此目的,通过 G 代码编写了打印过程文件,使用 Solidworks 模拟评估了 3D 支架的物理和机械性能,通过 SEM 观察了打印 3D 支架的多孔结构和压力拉伸性能,并进行了实验以测量其生物相容性。研究得出的结论是,打印出的支架具有高度多孔的结构和各向异性的机械性能。

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