Berkley D S, Hazlett L
Department of Anatomy/Cell Biology, Wayne State University, School of Medicine, Detroit, Mich.
Ophthalmic Res. 1987;19(3):187-92. doi: 10.1159/000265492.
The compound 2-chloroacetophenone has been used to stimulate tear secretion from human subjects, yet the morphological response of the lacrimal gland to this agent has not been experimentally determined. This study used light and electron microscopic techniques to examine the effect of this agent with time on the morphology of the mouse exorbital lacrimal gland. In brief, exposure to 2-chloroacetophenone vapor causes rapid exocytosis of acinar cell granules as well as vacuolation of the secretory and ductal epithelial cells. Concomitantly, intralobular ductal epithelial cells which are normally cuboidal in shape, enlarge in size and release electron-dense granules into the duct lumen. Within 15 min after exposure, acinar cells show a preponderance of cells containing only pale granules and the ductal epithelium returns to a more cuboidal shape. By 60 min after exposure, the gland is not readily distinguishable from the unexposed, control gland.
化合物2-氯苯乙酮已被用于刺激人体受试者的泪液分泌，但泪腺对该药物的形态学反应尚未通过实验确定。本研究使用光镜和电镜技术，研究该药物随时间对小鼠眶外泪腺形态的影响。简而言之，暴露于2-氯苯乙酮蒸气会导致腺泡细胞颗粒迅速胞吐，以及分泌和导管上皮细胞空泡化。与此同时，正常呈立方形的小叶内导管上皮细胞体积增大，并向管腔内释放电子致密颗粒。暴露后15分钟内，腺泡细胞中大多数细胞仅含有浅色颗粒，导管上皮恢复为更立方形的形状。暴露后60分钟，该腺体与未暴露的对照腺体难以区分。
