Are Celeste, Pérez Maria, Bosch Joan, Amat Mercedes
Laboratory of Organic Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona, 080028-Barcelona, Spain.
Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona, 08921-Santa Coloma de Gramenet, Spain.
Chem Commun (Camb). 2019 Jun 25;55(50):7207-7210. doi: 10.1039/c9cc03690c. Epub 2019 Jun 5.
An enantioselective formal synthesis of the marine alkaloid madangamine A using phenylglycinol-derived lactam 1 as the starting enantiomeric scaffold is reported. The synthesis involves the construction of the C-9 substituted diazatricyclic ABC core and the final closure of D and E rings from the polyunsaturated skipped intermediate 19.
