Laboratory of Organic Chemistry, Faculty of Pharmacy, and Institute of Biomedicine (IBUB), University of Barcelona, 08028-Barcelona, Spain.
Chem Commun (Camb). 2013 Apr 18;49(30):3149-51. doi: 10.1039/c3cc41104d. Epub 2013 Mar 11.
The enantioselective synthesis of advanced tetracyclic precursors of madangamine D, bearing rings ABCD of this alkaloid, is reported. The saturated 14-membered ring is assembled from functionalized diazatricyclic intermediates following either ring-closing metathesis or macrolactamization strategies.
报道了麦当胺 D 的四环前体的对映选择性合成，该前体具有该生物碱的 ABCD 环。饱和的 14 元环是通过闭环复分解或大环内酯化策略，从功能化的氮杂三环中间体中组装而成。
