Fakhar Mahdi, Nakhaei Maryam, Sharifpour Ali, Kalani Hamed, Banimostafavi Elham Sadat, Abedi Siavash, Safanavaei Sepideh, Aliyali Masoud
Toxoplasmosis Research Center, Iranian National Registry Center for Lophomoniasis (INRCL), Mazandaran University of Medical Sciences, PO Box 48471-91971, Sari, Iran.
Toxoplasmosis Research Center, School of Medicine, Department of Parasitology, Mazandaran University of Medical Sciences, Farah-Abad Road, PO Box 48471-91971, Sari, Iran.
Acta Parasitol. 2019 Jun;64(2):390-393. doi: 10.2478/s11686-019-00084-2. Epub 2019 Jun 5.
We report a case of lophomoniasis in an immunocompetent patient with acute paranasal sinusitis from the north of Iran whose disease was diagnosed by both microscopic and molecular methods.
The patient, a 40-year-old woman, suffered from upper respiratory infection, was referred to the Iranian National Registry Center for Lophomoniasis (INRCL) at the Mazandaran University of Medical Sciences, Sari, Iran, for diagnosis. A direct wet mount of nasal discharge revealed the flagellate protozoa morphologically identified Lophomonas blattarum. Moreover, through a specific polymerase chain reaction (PCR) of nasal discharge, a 214-bp band was observed, confirming the genus Lophomonas spp. The patient was treated successfully with metronidazole 500 mg t.i.d for 1 week.
To the best of our knowledge, this is the first molecular detection of lophomoniasis in the literature. According to our preliminary study, a reliable PCR test is available now for detecting the Lophomonas parasite.
我们报告了一例来自伊朗北部的免疫功能正常的急性鼻窦炎患者感染披发虫病的病例，其疾病通过显微镜检查和分子方法得以确诊。
该患者为一名40岁女性，患有上呼吸道感染，被转诊至伊朗萨里马赞德兰医科大学的伊朗披发虫病国家登记中心进行诊断。鼻分泌物直接湿片镜检发现了形态上可鉴定为巴氏披发虫的鞭毛虫原生动物。此外，通过对鼻分泌物进行特异性聚合酶链反应（PCR），观察到一条214 bp的条带，证实为披发虫属。患者接受甲硝唑500 mg每日三次治疗1周，治疗成功。
据我们所知，这是文献中首次对披发虫病进行分子检测。根据我们的初步研究，现在有可靠的PCR检测方法可用于检测披发虫寄生虫。
