Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8 St., 02-786 Warsaw, Poland.
Int J Mol Sci. 2019 Jun 4;20(11):2737. doi: 10.3390/ijms20112737.
Bacteria from the species are a part of the biota of skin and mucous membranes of the upper respiratory, gastrointestinal, or urogenital tracts of animals, but also, opportunistic pathogens. causes a variety of purulent infections, such as metritis, mastitis, pneumonia, and abscesses, which, in livestock breeding, generate significant economic losses. Although this species has been known for a long time, many questions concerning the mechanisms of infection pathogenesis, as well as reservoirs and routes of transmission of bacteria, remain poorly understood. Pyolysin is a major known virulence factor of that belongs to the family of cholesterol-dependent cytolysins. Its cytolytic activity is associated with transmembrane pore formation. Other putative virulence factors, including neuraminidases, extracellular matrix-binding proteins, fimbriae, and biofilm formation ability, contribute to the adhesion and colonization of the host tissues. However, data about the pathogen-host interactions that may be involved in the development of infection are still limited. The aim of this review is to present the current knowledge about the pathogenic potential and virulence of .
该物种的细菌是动物皮肤和黏膜上呼吸道、胃肠道或泌尿生殖道生物群的一部分，但也是机会性病原体。可引起各种化脓性感染，如子宫内膜炎、乳腺炎、肺炎和脓肿，这在畜牧业中会造成重大的经济损失。尽管该物种已经存在很长时间了，但关于感染发病机制的机制以及细菌的储存库和传播途径的许多问题仍知之甚少。溶细胞素是属于胆固醇依赖性细胞溶解素家族的 的主要已知毒力因子。其溶细胞活性与跨膜孔的形成有关。其他潜在的毒力因子，包括神经氨酸酶、细胞外基质结合蛋白、菌毛和生物膜形成能力，有助于宿主组织的黏附和定植。然而，关于可能参与 感染发展的病原体-宿主相互作用的数据仍然有限。本综述的目的是介绍关于 的致病潜力和毒力的现有知识。
