Department of Chemistry, College of Science, Northeast Forestry University, 26 Hexing Road, Harbin 150040, P. R. China.
Harbin First Specialist Hospital, 217 Hongwei Road, Harbin 150056, China.
Biomater Sci. 2019 Aug 1;7(8):3258-3265. doi: 10.1039/c9bm00570f. Epub 2019 Jun 6.
Carbon quantum dots are excellent photoluminescent materials because of their unique fluorescence properties. They are widely used in biomedical imaging due to their good biocompatibility. However, carbon quantum dots with antitumor activity have rarely been reported. Gallic acid (GA) is an anticancer agent and effective against many types of tumor cells. In this study, GA based carbon dots (GACDs) with fluorescence and antitumor activity were synthesized by a simple microwave-assisted method and characterized by transmission electron microscopy (TEM), and Fourier transformed infrared (FTIR) and X-ray photoelectron spectroscopy (XPS). Studies of optical properties indicated that the GACDs exhibited significant photoluminescence. In addition, we observed the antitumor activity of the GACDs using both cell-based assays and mouse xenograft tumors. Our results demonstrated that the GACDs can be used as both a bioimaging material and an antitumor agent, suggesting their great potential in future clinical applications.
碳量子点因其独特的荧光特性而成为优秀的光致发光材料。由于其良好的生物相容性，它们被广泛应用于生物医学成像。然而，具有抗肿瘤活性的碳量子点很少有报道。没食子酸（GA）是一种抗癌药物，对多种类型的肿瘤细胞都有疗效。在这项研究中，通过简单的微波辅助方法合成了具有荧光和抗肿瘤活性的基于没食子酸的碳点（GACDs），并通过透射电子显微镜（TEM）、傅里叶变换红外（FTIR）和 X 射线光电子能谱（XPS）进行了表征。光学性质研究表明，GACDs 表现出显著的光致发光。此外，我们还通过细胞实验和小鼠异种移植瘤观察了 GACDs 的抗肿瘤活性。我们的结果表明，GACDs 既可以用作生物成像材料，也可以用作抗肿瘤药物，这表明它们在未来的临床应用中有很大的潜力。
