Jiang Tao, Wang Ya-Nan, Qu Qiang, Qi Ting-Ting, Chen Yun-Dai, Qu Jian
Department of Cardiovascular Medicine.
Department of Respiratory, Hospital of Laiwu Iron and Steel Co. Ltd, Laiwu.
Medicine (Baltimore). 2019 Jun;98(23):e15953. doi: 10.1097/MD.0000000000015953.
Studies showed the controversial results about the effect of common genetic polymorphisms on the atrial fibrillation (AF) recurrence. We performed the systematic review and meta-analysis to qualify the association between common genetic polymorphisms and AF recurrence.
Articles were systematically retrieved PubMed, Web of Science, EMBASE, Wanfang, and CNKI database and 9 studies including 3204 patients were enrolled in our meta-analysis.
Results showed that the associations were significant under rs2200733 3 genetic models (TT vs CC: odds ratio [OR] [confidence interval [CI]] = 1.336 [1.061-1.683], P = .014; CT vs CC: OR [CI] = 0.759 [0.614-0.937], P = .01; TT vs CT + CC: OR [CI] = 2.308 [1.440-3.700], P = .001). The association was significant under rs10033464 genetic model (TT vs GG: OR [CI] = 1.517 [1.165-1.976], P = .002).
Rs13376333 on chromosome 1q21 (in KCNN3), rs7193343 and rs2106261 on chromosome 16q22 (in ZFHX3) were not associated with AF recurrence in our meta-analysis. In total, our meta-analysis found that rs2200733 and rs10033464 on chromosome 4q25 (near PITX2) were associated with the risk of AF recurrence.
研究显示，常见基因多态性对房颤（AF）复发的影响存在争议性结果。我们进行了系统评价和荟萃分析，以确定常见基因多态性与AF复发之间的关联。
通过系统检索PubMed、Web of Science、EMBASE、万方和知网数据库，纳入9项研究共3204例患者进行荟萃分析。
结果显示，在rs2200733的3种遗传模型下关联具有显著性（TT与CC比较：比值比[OR][置信区间[CI]] = 1.336[1.061 - 1.683]，P = 0.014；CT与CC比较：OR[CI] = 0.759[0.614 - 0.937]，P = 0.01；TT与CT + CC比较：OR[CI] = 2.308[1.440 - 3.700]，P = 0.001）。在rs10033464遗传模型下关联具有显著性（TT与GG比较：OR[CI] = 1.517[1.165 - 1.976]，P = 0.002）。
在我们的荟萃分析中，1号染色体q21（位于KCNN3基因）上的rs13376333、16号染色体q22（位于ZFHX3基因）上的rs7193343和rs2106261与AF复发无关。总体而言，我们的荟萃分析发现，4号染色体q25（靠近PITX2基因）上的rs2200733和rs10033464与AF复发风险相关。
