Zhang Feng Wei, Gao Jie, Zhang Su Li, Wu Cheng Pu, Li Yong, Bai Wen Jing, Feng Shun Yi
Emergency Department, Cangzhou Central Hospital, Yunhe Qu, Cangzhou, China.
Medicine (Baltimore). 2019 Jun;98(23):e15973. doi: 10.1097/MD.0000000000015973.
Although the prognostic significance of base excess (BE) in patients with paraquat (PQ) poisoning has been investigated for several years, the results remain controversial. Thus, we performed for the first time a comprehensive meta-analysis to explore the value of BE in predicting the prognosis of patients with PQ poisoning.
We searched PubMed, EMBase, Web of Science, ScienceDirect, Cochrane Library, and the Chinese National Knowledge Infrastructure to identify all relevant papers that were published up to August 2018. The data were extracted for pooled analysis, heterogeneity testing, sensitivity analysis, publication bias analysis, and subgroup analysis.
Pooled analysis revealed that a decreased BE is correlated with poor mortality (pooled OR = 21.358, 95% CI: 12.716-35.873, P < .001). Pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 78% (95% CI: 0.66-0.86), 88% (95% CI: 0.66-0.97), 6.6 (95% CI: 2.2-19.9), 0.25 (95% CI: 0.18-0.36), and 26 (10-69), respectively. No publication bias was detected by Egger test (P = .263) and Begg test (P = .462). Sensitivity analyses indicated no important differences among the estimates of effects.
Our findings show that BE is useful for predicting the prognosis of PQ poisoning.
尽管百草枯（PQ）中毒患者碱剩余（BE）的预后意义已被研究多年，但其结果仍存在争议。因此，我们首次进行了一项全面的荟萃分析，以探讨BE在预测PQ中毒患者预后方面的价值。
我们检索了PubMed、EMBase、Web of Science、ScienceDirect、Cochrane图书馆和中国知网，以识别截至2018年8月发表的所有相关论文。提取数据进行汇总分析、异质性检验、敏感性分析、发表偏倚分析和亚组分析。
汇总分析显示，BE降低与死亡率升高相关（汇总OR=21.358，95%CI：12.716-35.873，P<0.001）。汇总的敏感性、特异性、阳性似然比、阴性似然比和诊断比值比分别为78%（95%CI：0.66-0.86）、88%（95%CI：0.66-0.97）、6.6（95%CI：2.2-19.9）、0.25（95%CI：0.18-0.36）和26（10-69）。Egger检验（P=0.263）和Begg检验（P=0.462）未检测到发表偏倚。敏感性分析表明效应估计值之间无重要差异。
我们的研究结果表明，BE有助于预测PQ中毒的预后。
