Emergency Department, Cangzhou Central Hospital, Yunhe Qu, Cangzhou, China.
Laboratory Department, Yutian County Hospital, Yutian Xian, Tangshan, China.
PLoS One. 2018 Nov 16;13(11):e0207725. doi: 10.1371/journal.pone.0207725. eCollection 2018.
Sequential organ failure assessment (SOFA) score is commonly used to determine disease severity and predict prognosis in critically ill patients. However, the prognostic value of SOFA after acute paraquat (PQ) poisoning remains unclear. This meta-analysis aimed to study the capability of SOFA to predict mortality in patients with PQ poisoning. Databases that included PubMed, Embase, Web of Science, ScienceDirect, Embase, and Cochrane Library were searched through May 2018. Six studies involving 946 patients were included in the meta-analysis. Study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were calculated, and then ORs with 95% CIs were pooled for the estimation of the prognostic role of SOFA in patients with PQ poisoning. Results showed that higher SOFA in patients with PQ poisoning was related to severe mortality (OR = 8.14, 95%CI 4.26-15.58, p<0.001). The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic OR, and area under the curve were 72% (95%CI 0.65-0.79), 75% (95%CI 0.65-0.83), 2.9 (95%CI 2.0-4.1), 0.37 (95%CI 0.28-0.41), 8 (95%CI 4-14), and 0.79 (95%CI 0.76-0.83), respectively. No evidence of publication bias was detected by funnel plot analysis and formal statistical tests. Sensitivity analyses showed no important differences in the estimates of effects. The high SOFA score (8.1-fold) was associated with severe mortality in patients with PQ poisoning.
序贯器官衰竭评估（SOFA）评分常用于评估危重症患者的疾病严重程度和预测预后。然而，急性百草枯（PQ）中毒后 SOFA 的预后价值尚不清楚。本荟萃分析旨在研究 SOFA 预测 PQ 中毒患者死亡率的能力。通过 2018 年 5 月检索 PubMed、Embase、Web of Science、ScienceDirect、Embase 和 Cochrane Library 等数据库。纳入的 6 项研究共 946 例患者纳入荟萃分析。计算了研究特异性比值比（OR）和 95%置信区间（CI），然后合并 OR 和 95%CI 以评估 SOFA 在 PQ 中毒患者中的预后作用。结果表明，PQ 中毒患者 SOFA 较高与严重死亡率相关（OR=8.14，95%CI 4.26-15.58，p<0.001）。汇总的敏感性、特异性、阳性似然比、阴性似然比、诊断 OR 和曲线下面积分别为 72%（95%CI 0.65-0.79）、75%（95%CI 0.65-0.83）、2.9（95%CI 2.0-4.1）、0.37（95%CI 0.28-0.41）、8（95%CI 4-14）和 0.79（95%CI 0.76-0.83）。漏斗图分析和正式的统计检验未发现发表偏倚的证据。敏感性分析表明，效应估计值无重要差异。SOFA 评分较高（8.1 倍）与 PQ 中毒患者的严重死亡率相关。
