Zhang Weijun
Department of Clinical Laboratory Center, the Second Hospital of Lanzhou University, Lanzhou, China.
Medicine (Baltimore). 2019 Jun;98(23):e15977. doi: 10.1097/MD.0000000000015977.
Tuberculosis (TB) is a highly contagious and chronic disease. The microbiological examination to confirm children TB disease are limited due to paucibacillary Mycobacterium, specimens and detecting facilities. Considering these limitations in diagnosing children TB, new and reliable methods that detect children TB should be developed. Recently, Interferon gamma-induced protein 10 (IP-10) has been identified as a sensitive parameter in detecting children TB. The present study aims to synthesis and analysis the diagnostic value of IP-10 for children TB.
We will search PubMed, Embase, the Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure, and Chinese Biological Medical Databases. We will search relevant citations up to May 2019. The quality of individual study will be assessed using the Quality Assessment of Diagnostic Accuracy Studies tool-2 (QUADAS-2). Stata 14.0 software will be used to calculate the pooled sensitivity, pooled specificity, pooled positive likelihood ratio (PLR), pooled negative likelihood ratio (NLR), pooled diagnostic odds ratio (DOR), pre-test probability, post-test probability and the hierarchical summary receiver operating characteristic (HSROC) curve.
The results of this study will be published in a peer-reviewed journal.
The evidence will indicate that IP-10 test is an alternative immunological test in detecting children TB. This is a protocol of systematic review and meta-analysis, so the ethical approval and patient consent are not required.
CRD42019129743.
结核病是一种具有高度传染性的慢性疾病。由于结核分枝杆菌数量少、标本及检测设施等原因，用于确诊儿童结核病的微生物学检查受到限制。考虑到儿童结核病诊断中的这些局限性，应开发新的、可靠的检测儿童结核病的方法。最近，干扰素γ诱导蛋白10（IP-10）已被确定为检测儿童结核病的一个敏感参数。本研究旨在综合分析IP-10对儿童结核病的诊断价值。
我们将检索PubMed、Embase、Cochrane图书馆、Web of Science、中国知网和中国生物医学数据库。我们将检索截至2019年5月的相关文献。将使用诊断准确性研究质量评估工具-2（QUADAS-2）评估个体研究的质量。将使用Stata 14.0软件计算合并敏感度、合并特异度、合并阳性似然比（PLR）、合并阴性似然比（NLR）、合并诊断比值比（DOR）、验前概率、验后概率以及分层汇总接受者操作特征（HSROC）曲线。
本研究结果将发表在同行评审期刊上。
证据将表明IP-10检测是检测儿童结核病的一种替代免疫学检测方法。这是一项系统评价和荟萃分析方案，因此不需要伦理批准和患者同意。
CRD42019129743。
