National Reference Center for Arboviruses, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium; Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel, Department of Microbiology, Brussels, Belgium.
Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel, Department of Microbiology, Brussels, Belgium.
Diagn Microbiol Infect Dis. 2019 Oct;95(2):144-148. doi: 10.1016/j.diagmicrobio.2019.05.004. Epub 2019 May 10.
Because Zika virus (ZIKV) can cause serious birth defects and is involved in cases of Guillain-Barré syndrome, the ZIKV outbreak in the American continent in 2015 resulted in an enormous need for ZIKV diagnostic tools. We evaluated the LIAISON® XL Zika Capture IgM test on 106 samples from patients, mainly travelers, with a confirmed or probable ZIKV infection. Sensitivity between 0 and 84 days after onset of symptoms was 92.5%. Specificity was evaluated on a panel of 56 samples known to cause possible cross-reactions. Cross-reaction with DENV antibodies was limited (10.5%) but false-positive results occurred in samples from patients with malaria, CMV and EBV infections.
由于寨卡病毒（ZIKV）可导致严重的出生缺陷，并与吉兰-巴雷综合征有关，因此，2015 年美洲大陆的寨卡病毒爆发导致对寨卡病毒诊断工具的巨大需求。我们评估了 LIAISON®XL Zika Capture IgM 检测试剂盒对 106 份来自确诊或疑似寨卡病毒感染患者（主要为旅行者）样本的检测性能。症状出现后 0 至 84 天的敏感性为 92.5%。我们在一个已知可能发生交叉反应的 56 份样本的面板上评估了特异性。与登革热病毒抗体的交叉反应有限（10.5%），但疟疾、巨细胞病毒和 EBV 感染患者的样本中出现了假阳性结果。
