Schneider W, Krumpl G, Mayer N, Raberger G
Institut für Pharmakologie der Universität Wien, Austria.
Br J Pharmacol. 1987 Sep;92(1):87-95. doi: 10.1111/j.1476-5381.1987.tb11299.x.
1 Because controversy exists regarding the effects of dihydroergotamine (DHE) on the performance of underperfused myocardium, the effects of DHE were investigated in a model of exercise-induced regional myocardial dysfunction in conscious dogs. 2 We also investigated a possible functional antagonism between DHE and nitroglycerin that might reduce the latter drug's antianginal efficacy. 3 Investigations were carried out in conscious dogs. After stenosis of the circumflex branch of the left coronary artery that minimally affected resting myocardial function, treadmill exercise induced transient regional contractile dysfunction. Heart rate, arterial blood pressure, left ventricular dp/dtmax and left ventricular end-diastolic pressure were registered. Regional contractile performance was assessed by ultrasonic distance measurement in the underperfused and in a normally perfused area. 4 DHE (5 micrograms kg-1, i.v.) induced a decrease in left ventricular dp/dtmax at rest and during exercise. DHE did not cause a deterioration in contractile function in the ischaemic myocardium, but led to a slight although not significant improvement in regional myocardial function. 5 After pretreatment with DHE, infusion of nitroglycerin (15 micrograms kg-1, i.v.) induced an improvement in the underperfused myocardial area during treadmill exercise, accompanied by a decrease in diastolic arterial pressure and left ventricular end-diastolic pressure and an increase in left ventricular dp/dtmax. 6 These results suggest that DHE will not worsen exercise-induced angina pectoris, and that the antianginal efficacy of nitroglycerin will not be neutralized by pretreatment with DHE.
1 由于关于双氢麦角胺（DHE）对灌注不足心肌功能的影响存在争议，因此在清醒犬运动诱导的局部心肌功能障碍模型中研究了DHE的作用。2 我们还研究了DHE与硝酸甘油之间可能存在的功能性拮抗作用，这种拮抗作用可能会降低后者的抗心绞痛疗效。3 在清醒犬身上进行了研究。在对静息心肌功能影响最小的左冠状动脉回旋支狭窄后，跑步机运动诱导了短暂的局部收缩功能障碍。记录心率、动脉血压、左心室dp/dtmax和左心室舒张末期压力。通过超声距离测量评估灌注不足区域和正常灌注区域的局部收缩性能。4 DHE（5微克/千克，静脉注射）在静息和运动期间导致左心室dp/dtmax降低。DHE并未导致缺血心肌收缩功能恶化，但导致局部心肌功能有轻微改善，尽管不显著。5 在DHE预处理后，输注硝酸甘油（15微克/千克，静脉注射）在跑步机运动期间使灌注不足的心肌区域得到改善，同时舒张压和左心室舒张末期压力降低，左心室dp/dtmax增加。6 这些结果表明，DHE不会使运动诱导的心绞痛恶化，并且硝酸甘油的抗心绞痛疗效不会因DHE预处理而被抵消。
