Müller-Schweinitzer E
J Pharmacol Methods. 1984 Aug;12(1):53-8. doi: 10.1016/0160-5402(84)90006-8.
Determinations of drug-induced changes in venous compliance were performed in conscious dogs using a linear variable differential transformer. Changes in the diameter of the canine saphenous vein, produced by inflation to 45 mmHg of a sphygmomanometer cuff placed on the upper hind leg, were recorded. The cuff was inflated at 5-min intervals for 2 min before and after drug administration. Validation studies of this new method were performed by investigating the venoconstrictor activity of dihydroergotamine (Dihydergot). The intravenous administration of DHE, either locally or systemically, elicited dose-dependent and longlasting venoconstrictor responses with extremely small interindividual variations. Comparison of the present results to those reported for man suggests that recording of venous compliance in the conscious dog provides data with good predictability.
使用线性可变差动变压器，在清醒犬中测定药物引起的静脉顺应性变化。通过将置于后肢上部的血压计袖带充气至45 mmHg，记录犬隐静脉直径的变化。在给药前后，袖带每隔5分钟充气2分钟。通过研究双氢麦角胺（Dihydergot）的静脉收缩活性，对这种新方法进行了验证研究。局部或全身静脉注射双氢麦角胺均可引起剂量依赖性和持久的静脉收缩反应，个体间差异极小。将目前的结果与报道的人类结果进行比较表明，清醒犬静脉顺应性的记录提供了具有良好可预测性的数据。
