Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Curr Nutr Rep. 2019 Sep;8(3):212-221. doi: 10.1007/s13668-019-00278-0.
Breast cancer is the most common cancer in women, yet conclusive evidence of the effects of dietary modification in breast cancer survivors is lacking. Here, we summarize the literature and highlight important data regarding the association between dietary interventions and breast cancer outcomes.
Long-term follow-up and secondary analysis of the Women's Health Initiative study demonstrated a significant improvement in overall survival for women who were randomized to the low-fat diet pattern compared with those in the usual-diet group. Dietary quality as measured by Healthy Eating Index score was also associated with both a decrease in cancer-specific mortality and overall mortality. Despite current evidence on the role of diet and nutrition in breast cancer outcomes, conclusive data to translate current findings to clinical practice is lacking and requires multidisciplinary prospective research to advance the field.
乳腺癌是女性最常见的癌症,但饮食调整对乳腺癌幸存者影响的确切证据仍缺乏。在这里,我们总结了相关文献,并重点介绍了饮食干预与乳腺癌结局之间关联的重要数据。
妇女健康倡议研究的长期随访和二次分析表明,与常规饮食组相比,随机分配到低脂饮食模式的女性总生存率显著提高。用健康饮食指数评分衡量的饮食质量也与癌症特异性死亡率和总死亡率的降低相关。尽管目前有关于饮食和营养在乳腺癌结局中的作用的证据,但将这些发现转化为临床实践的结论性数据仍然缺乏,需要多学科的前瞻性研究来推动该领域的发展。