克拉霉素对废活性污泥厌氧发酵产生挥发性脂肪酸的影响。
Effect of clarithromycin on the production of volatile fatty acids from waste activated sludge anaerobic fermentation.
机构信息
College of Environmental Science and Engineering, Hunan University, Changsha 410082, China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, China.
College of Environmental Science and Engineering, Hunan University, Changsha 410082, China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, China.
出版信息
Bioresour Technol. 2019 Sep;288:121598. doi: 10.1016/j.biortech.2019.121598. Epub 2019 Jun 1.
This study investigated the effect of Clarithromycin (CLA) on volatile fatty acids (VFAs) production during waste activated sludge (WAS) anaerobic fermentation for the first time. Experimental results showed that when CLA concentration in WAS increased from 0 to 1000 mg/kg TSS, the maximum yield of VFAs increased from 27.7 to 35.7 mg COD/g VSS (without pH pretreatment) and from 59.3 to 65.6 mg COD/g VSS (initial pH 9 pretreatment), respectively. Mechanism exploration revealed that CLA facilitated the disruption of extracellular polymeric substances, thus promoting WAS solubilization. CLA inhibited all the other anaerobic fermentation processes. However, its inhibition to acetogenesis and methanogenesis was severer than that to hydrolysis and acidogenesis, resulting in the decrease in VFAs consumption. Microbial analysis showed that CLA slightly increased the abundance of microorganisms responsible for hydrolysis and acidogenesis whereas decreased the proportion of VFAs-consuming microorganisms.
本研究首次考察了克拉霉素（CLA）对剩余活性污泥（WAS）厌氧发酵过程中挥发性脂肪酸（VFAs）生成的影响。实验结果表明，当 CLA 浓度从 0 增加到 1000mg/kg TSS 时，VFAs 的最大产量从 27.7 增加到 35.7mg COD/g VSS（无 pH 预处理）和从 59.3 增加到 65.6mg COD/g VSS（初始 pH 9 预处理）。机理探讨表明，CLA 有助于破坏胞外聚合物，从而促进 WAS 的溶解。CLA 抑制了所有其他厌氧发酵过程。然而，它对产乙酸和产甲烷的抑制作用比水解和产酸更严重，导致 VFAs 的消耗减少。微生物分析表明，CLA 略微增加了负责水解和产酸的微生物的丰度，而降低了消耗 VFAs 的微生物的比例。
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