Department of Medical Sciences and Public Health, Section of Neurology, University of Cagliari, ss.554 km 4.500 09042 Monserrato, Cagliari, Italy.
Department of Mechanical, Chemical and Materials Engineering, University of Cagliari, Cagliari, Italy.
Exp Brain Res. 2019 Aug;237(8):2105-2110. doi: 10.1007/s00221-019-05575-2. Epub 2019 Jun 8.
Dementia with Lewy body is a neurodegenerative disorder affecting both cognitive and motor domains. Motor impairment manifests predominantly as a symmetrical/mild asymmetrical parkinsonian syndrome that is only mildly responsive to Levodopa. To characterize motor dysfunction in dementia with Lewy body, we quantitatively assessed upper limb movements using a motion-capture system. Ten patients and ten healthy controls were tested while performing the hand-to-mouth movement of which speed, smoothness and accuracy features were measured. The results showed that individuals with dementia with Lewy body required a longer time to complete the task, particularly due to a prolonged duration of the adjusting phase (i.e., when approaching the target/mouth). The overall motor performance of dementia with Lewy body patients closely resembled what previously observed in patients affected by both Parkinson's disease and ataxia while performing the same task. Moreover, the severity of parkinsonian symptoms as assessed by the UPDRS-III scale impacted on the velocity of movement alone whereas impairment of executive functions correlated with variables related to the phase of targeting the mouth. This study provides new information about upper limb motor dysfunction in dementia with Lewy body.
路易体痴呆是一种影响认知和运动领域的神经退行性疾病。运动障碍主要表现为对称/轻度不对称的帕金森综合征，对左旋多巴的反应仅轻度。为了描述路易体痴呆中的运动功能障碍，我们使用运动捕捉系统对上肢运动进行了定量评估。十名患者和十名健康对照者在执行手到嘴的运动时接受了测试，测量了速度、平滑度和准确性特征。结果表明，路易体痴呆患者完成任务所需的时间更长，特别是由于调整阶段（即接近目标/嘴）的持续时间延长。路易体痴呆患者的整体运动表现与以前在帕金森病和共济失调患者执行相同任务时观察到的非常相似。此外，UPDRS-III 量表评估的帕金森症状严重程度仅影响运动速度，而执行功能障碍与与瞄准嘴的阶段相关的变量相关。这项研究提供了关于路易体痴呆中上肢运动功能障碍的新信息。
