Department of Clinical Nutrition, The Catholic University of Korea Seoul St, Mary's Hospital, Seoul, Republic of Korea.
Department of Public Health, Graduate School of Public Health & Institute of Health and Environment, Seoul National University, Gwanak-gu, Seoul 08826, Republic of Korea.
Br J Nutr. 2019 Aug 14;122(3):322-330. doi: 10.1017/S000711451900117X. Epub 2019 Jun 10.
The present study investigated the association between protein intake and lean mass according to obesity status over a 12-year period. Data on 4412 participants aged 40-69 years were obtained from the Korean Genome and Epidemiology Study. The usual dietary protein intake of these participants was assessed at baseline using a semi-quantitative FFQ. Body composition was measured using bioelectrical impedance analysis at baseline and after a 12-year follow-up. Linear mixed-effects models were used to examine the associations between lean mass after a 12-year follow-up and protein intake at baseline. After adjusting for covariates and lean mass at baseline, comparisons between the highest and lowest tertiles revealed that dietary protein intake was positively associated with lean mass in both men (β = 0·79, P = 0·001) and women (β = 0·28, P = 0·082) after the 12-year period; however, those differences were attenuated after additional adjustment for fat mass at baseline and were stronger in the normal-weight group (men, β = 0·85, P = 0·002; women, β = 0·97, P < 0·001) but were not detected in the obese group. In the obese group, age (men, β = 4·08, P < 0·001; women, β = 2·61, P < 0·001) and regular physical activity (men, β = 0·88, P = 0·054; women, β = 0·76, P < 0·001) were significantly associated with lean mass after 12 years of follow-up. The results of the present study showed that protein intake may contribute to the prevention of ageing-related lean mass loss; however, the impact of this intake may vary depending on obesity status. Therefore, the maintenance of a healthy body weight during ageing through enhanced protein intake is likely to confer health benefits.
本研究调查了在 12 年期间，根据肥胖状况，蛋白质摄入量与瘦体重之间的关系。这项研究的数据来自韩国基因组与流行病学研究，共纳入了 4412 名年龄在 40-69 岁的参与者。这些参与者的常规膳食蛋白质摄入量在基线时使用半定量食物频率问卷进行评估。在基线和 12 年随访后，使用生物电阻抗分析测量身体成分。线性混合效应模型用于检验 12 年随访后瘦体重与基线时蛋白质摄入量之间的关系。在校正协变量和基线时的瘦体重后，最高和最低三分位组之间的比较显示，在男性（β=0.79，P=0.001）和女性（β=0.28，P=0.082）中，膳食蛋白质摄入量与 12 年后的瘦体重呈正相关；然而，在进一步校正基线时的脂肪量后，这些差异减弱，在正常体重组中更强（男性，β=0.85，P=0.002；女性，β=0.97，P<0.001），但在肥胖组中未检测到。在肥胖组中，年龄（男性，β=4.08，P<0.001；女性，β=2.61，P<0.001）和规律的体育活动（男性，β=0.88，P=0.054；女性，β=0.76，P<0.001）与 12 年后的瘦体重显著相关。本研究结果表明，蛋白质摄入可能有助于预防与年龄相关的瘦体重丢失；然而，这种摄入的影响可能因肥胖状况而异。因此，通过增加蛋白质摄入来维持健康的体重可能会带来健康益处。
