Braidy Nady, Villalva Maria D, van Eeden Sam
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney NSW 2052, Australia.
Centre for Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK.
Antioxidants (Basel). 2020 May 14;9(5):425. doi: 10.3390/antiox9050425.
Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that has garnered considerable interest in the last century due to its critical role in cellular processes associated with energy production, cellular protection against stress and longevity. Research in NAD+ has been reinvigorated by recent findings that components of NAD+ metabolism and NAD-dependent enzymes can influence major signalling processes associated with the neurobiology of addiction. These studies implicate raising intracellular NAD+ levels as a potential target for managing and treating addictive behaviour and reducing cravings and withdrawal symptoms in patients with food addiction and/or substance abuse. Since clinical studies showing the use of NAD+ for the treatment of addiction are limited, this review provides literature evidence that NAD+ can influence the neurobiology of addiction and may have benefits as an anti-addiction intervention.
烟酰胺腺嘌呤二核苷酸（NAD+）是一种必需的吡啶核苷酸，由于其在与能量产生、细胞应激保护和长寿相关的细胞过程中发挥关键作用，在上个世纪引起了广泛关注。最近的研究发现，NAD+代谢成分和NAD依赖性酶可以影响与成瘾神经生物学相关的主要信号传导过程，这使得对NAD+的研究重新焕发生机。这些研究表明，提高细胞内NAD+水平可能是管理和治疗成瘾行为、减少食物成瘾和/或药物滥用患者的渴望及戒断症状的一个潜在靶点。由于使用NAD+治疗成瘾的临床研究有限，本综述提供了文献证据，证明NAD+可以影响成瘾的神经生物学，并且作为一种抗成瘾干预措施可能有益。
