State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
University of Chinese Academy of Sciences , Beijing 100049 , China.
Org Lett. 2019 Jun 21;21(12):4554-4558. doi: 10.1021/acs.orglett.9b01453. Epub 2019 Jun 10.
Four unprecedented yellow alkaloids named as taberbovines A-D (1-4) were isolated from stems of Tabernaemontana bovina Lour. Their structures were elucidated by the comprehensive spectroscopic data, computational chemistry, and X-ray crystal diffraction. Alkaloids 1-4 possessed a unique 6/6/5/6/5 ring system and were assigned to monoterpenoid quinolines. Biosynthetically, the isolated alkaloids may be derived from Aspidosperma-type alkaloid by oxidation and rearrangements. Taberbovines A-D exhibited the good inhibitory activities of formation NO in LPS induced RAW264.7 macrophages.
从 Tabernaemontana bovina Lour 的茎中分离得到了四个前所未有的黄色生物碱，分别命名为 taberbovines A-D（1-4）。通过综合光谱数据、计算化学和 X 射线晶体衍射确定了它们的结构。生物碱 1-4 具有独特的 6/6/5/6/5 环系统，被归类为单萜喹啉。生物合成上，这些分离出的生物碱可能是通过氧化和重排来自 Aspidosperma 型生物碱。Taberbovines A-D 对 LPS 诱导的 RAW264.7 巨噬细胞中 NO 的形成具有良好的抑制活性。
