从 Lour（夹竹桃科）茎中提取的新单萜吲哚生物碱。
New monoterpenoid indole alkaloids from the stems of Lour (Apocynaceae).
机构信息
School of Biological Science and Technology, University of Jinan, Jinan, China.
Key Laboratory of Natural Pharmaceutical Chemistry, Shandong University of Traditional Chinese Medicine, Jinan, China.
出版信息
Nat Prod Res. 2024 Jul;38(14):2447-2452. doi: 10.1080/14786419.2023.2180503. Epub 2023 Feb 14.
Two new monoterpenoid indole alkaloids, named taberibogines E and F ( and ), together with three known ones (-) were isolated from the stems of Lour (Apocynaceae). Their structures including absolute configurations were elucidated from a combination of NMR and HRESIMS data and NMR calculations as well as DP4+ probability analyses. Compounds and exhibited inhibitory effects on LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages.
从 Tabernaemontana divaricata（夹竹桃科）的茎中分离得到了两种新的单萜吲哚生物碱，分别命名为 taberibogines E 和 F（ 和 ），以及三种已知化合物（-）。通过 NMR 和 HRESIMS 数据以及 NMR 计算和 DP4+概率分析的组合，阐明了它们的结构，包括绝对构型。化合物 和 对 LPS 诱导的 RAW 264.7 巨噬细胞中一氧化氮（NO）的产生具有抑制作用。
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