Vanerio Noemi, Stijnen Marco, de Mol Bas A J M, Kock Linda M
1 LifeTec Group BV, Eindhoven, The Netherlands.
2 Department of Cardiothoracic Surgery & Cardiovascular Sciences, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Photobiomodul Photomed Laser Surg. 2019 Jul;37(7):383-394. doi: 10.1089/photob.2018.4604. Epub 2019 Jun 10.
The aim of this review is to discuss and compare the extensive range of biomedical applications of photo- and sono-activated Rose Bengal (RB). RB is a xanthene dye that due to its interesting photo- and sono-sensitive properties is gaining attention in the scientific field. This study is a literature review using the database PubMed. As a photosensitizer, RB converts the triplet oxygen molecule into reactive oxygen species after irradiation with green light (532 nm). This mechanism allows for the use of photo-activated RB in photochemical tissue bonding, photodynamic therapy, antimicrobial therapy and cancer treatment, photothrombotic animal models, and other applications, including tissue engineering and treatment of tauopathies. As a sono-sensitive compound, RB is applied for sonodynamic therapy, cancer treatment, and antimicrobial therapy. This review outlines the versatility and effectiveness of photo- and sono-activated RB in numerous biomedical applications.
本综述的目的是讨论和比较光激活和声激活孟加拉玫瑰红（RB）在广泛生物医学应用中的情况。RB是一种呫吨染料，由于其有趣的光敏感和声敏感特性，正在科学界受到关注。本研究是一项使用PubMed数据库的文献综述。作为一种光敏剂，RB在绿光（532nm）照射后将三线态氧分子转化为活性氧。这种机制使得光激活的RB可用于光化学组织黏合、光动力疗法、抗菌疗法和癌症治疗、光血栓形成动物模型以及其他应用，包括组织工程和tau蛋白病的治疗。作为一种声敏感化合物，RB应用于声动力疗法、癌症治疗和抗菌疗法。本综述概述了光激活和声激活RB在众多生物医学应用中的多功能性和有效性。
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