Bartusik-Aebisher Dorota, Przygórzewska Agnieszka, Woźnicki Paweł, Aebisher David
Department of Biochemistry and General Chemistry, Faculty of Medicine, Collegium Medicum, University of Rzeszów, 35-310 Rzeszów, Poland.
English Division Science Club, Faculty of Medicine, Collegium Medicum, University of Rzeszów, 35-310 Rzeszów, Poland.
Molecules. 2025 Mar 31;30(7):1571. doi: 10.3390/molecules30071571.
Photodynamic therapy (PDT) is a therapeutic method based on the interaction between light and a photosensitizer. Supported by nanoparticles, this method represents a promising interdisciplinary approach for the treatment of many diseases. This article reviews the latest 2024 developments in the design and applications of nanoparticles dedicated to stand-alone PDT of breast cancer. Strategies to improve therapeutic efficacy by enhancing reactive oxygen species (ROS) production, precise delivery of photosensitizers and their stabilization in the systemic circulation are discussed, among others. Results from preclinical studies indicate significant improvements in therapeutic efficacy, including inhibition of tumor growth, reduction in metastasis and improvement of the immune microenvironment. The potential of these technologies to expand PDT applications in medicine and the need for further clinical trials to confirm their safety and efficacy are highlighted.
光动力疗法（PDT）是一种基于光与光敏剂相互作用的治疗方法。在纳米颗粒的支持下，该方法是一种治疗多种疾病的有前景的跨学科方法。本文综述了2024年用于乳腺癌独立光动力疗法的纳米颗粒设计与应用的最新进展。讨论了通过增强活性氧（ROS）生成、光敏剂的精确递送及其在体循环中的稳定性等提高治疗效果的策略。临床前研究结果表明治疗效果有显著改善，包括抑制肿瘤生长、减少转移和改善免疫微环境。强调了这些技术在扩大光动力疗法在医学中的应用潜力以及进一步进行临床试验以确认其安全性和有效性的必要性。
