Matsumura K, Sawada K, Fukuma S, Kuwahara T, Maruyama K
Division of Thoracic Surgery, Chiba Cancer Center.
Gan No Rinsho. 1987 Sep;33(11):1337-42.
Mitomycin C (MMC) was incorporated into liquid silicone which was then vulcanized into solid form. Pellets of MMC were implanted at 5 different sites within the mediastinum of 9 dogs. Implants were removed at regular intervals after sacrificing the test animals. Though the mean doses of MMC released leveled off during 4 weeks, it began to increased rapidly after the 5 week with the result of, this one month delay compared with in vitro. Necrosis appeared to prevent MMC from liberating itself from the implants. Further, the cumulative doses of MMC released were found to be superior in the subaortic and subcarinal sites than in the other three places. No serious complications were encountered in this study.
丝裂霉素C（MMC）被掺入液态硅酮中，然后硫化成固体形式。将MMC微丸植入9只狗纵隔内的5个不同部位。在处死实验动物后定期取出植入物。尽管MMC的平均释放剂量在4周内趋于平稳，但在第5周后开始迅速增加，结果比体外实验延迟了1个月。坏死似乎阻止了MMC从植入物中释放出来。此外，发现MMC在主动脉下和隆突下部位的累积释放剂量高于其他三个部位。本研究未遇到严重并发症。
