Department of Veterans Affairs Medical Center, Orthopaedic Research Laboratory, Salt Lake City, UT, 84148, USA.
Division of Plastic Surgery, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT, 84132, USA.
J Mater Sci Mater Med. 2019 Jun 10;30(6):71. doi: 10.1007/s10856-019-6272-4.
Biomimetic material coatings and negative pressure wound therapy (NPWT) have been shown independently to limit the epithelial downgrowth rates in percutaneous devices. It was therefore hypothesized that these techniques, in combination, could further limit the clinically observed epithelial downgrowth around these devices. In this study, we evaluated the efficacy of two biomimetic coatings, collagen and hydroxyapatite (HA), to prevent downgrowth when used with continuous NPWT. Using an established single-stage surgical protocol, collagen (n = 10) and HA (n = 10) coated devices were implanted subdermally on the back of hairless guinea pigs. Five animals from each group were subjected to continuous ~90 mmHg NPWT. Four weeks post-implantation, animals were sacrificed, and the devices and surrounding tissues were harvested, processed, and downgrowth was computed and compared to historical porous titanium coated controls. Data showed a significant reduction in downgrowth in NPWT treated animals (p ≤ 0.05) when compared to the untreated porous titanium controls. HA coated devices, without the NPWT treatment, also showed significantly decreased downgrowth compared to the untreated porous titanium controls.
仿生材料涂层和负压伤口治疗（NPWT）已被证明可以独立限制经皮装置中上皮向下生长的速度。因此，研究假设这些技术联合使用可以进一步限制这些装置周围临床观察到的上皮向下生长。在这项研究中，我们评估了两种仿生涂层（胶原蛋白和羟基磷灰石（HA））在与持续 NPWT 一起使用时预防向下生长的效果。使用已建立的单阶段手术方案，将胶原蛋白（n=10）和 HA（n=10）涂层装置皮下植入无毛豚鼠背部。每组 5 只动物接受持续约 90mmHg 的 NPWT。植入后 4 周，处死动物，收获装置和周围组织，并计算向下生长情况，并与历史多孔钛涂层对照进行比较。数据显示，与未治疗的多孔钛对照组相比，NPWT 治疗的动物的向下生长显著减少（p≤0.05）。未接受 NPWT 治疗的 HA 涂层装置与未治疗的多孔钛对照组相比，向下生长也明显减少。
