Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Int Wound J. 2013 Dec;10 Suppl 1(Suppl 1):15-9. doi: 10.1111/iwj.12170.
Negative pressure wound therapy (NPWT), which was introduced as a commercial product (V.A.C. Therapy, KCI USA, Inc., San Antonio, TX) less than 20 years ago, has revolutionised the treatment of complex wounds. Indicated for wide variety of wound types, NPWT is an adjunctive therapy that can be used safely in a range of care settings. Current research indicates that there are four primary NPWT mechanisms of action: macrodeformation, microdeformation, fluid removal and environmental control of the wound. The interaction of the primary mechanisms results in secondary effects through cell signalling (e.g. granulation tissue formation, cell proliferation and modulation of inflammation). Better understanding of the mechanisms of action also provides insight into future directions for NPWT research that could create better solutions for patients with complex wounds.
负压伤口治疗（NPWT）作为一种商业产品（V.A.C. Therapy，KCI USA，Inc.，圣安东尼奥，TX）不到 20 年前推出，彻底改变了复杂伤口的治疗方法。适用于各种类型的伤口，NPWT 是一种辅助治疗，可以在各种护理环境中安全使用。目前的研究表明，NPWT 有四种主要的作用机制：宏观变形、微观变形、液体清除和伤口环境控制。主要机制的相互作用通过细胞信号传导产生次要作用（例如肉芽组织形成、细胞增殖和炎症调节）。更好地了解作用机制也为 NPWT 研究的未来方向提供了深入的了解，这可能为复杂伤口患者创造更好的解决方案。
