Iakovleva N V, Pokhodzeĭ I V, Tovt-Korshinskaia M I, Sukhovskaia O A
Ter Arkh. 1987;59(7):47-50.
Virological and immunological studies on 53 patients with chronic obstructive bronchitis at the clinical stage of fading exacerbation were conducted. A high percentage of active viral infection (43%), persistence of viruses (25%) and virus-specific components (ribonucleoprotein in influenza) in the cells of brush biopsy bronchial mucosa specimens was characteristic for these patients. The respiratory-syncytial virus was the most common persisting virus (11%). A high percentage of association (72%) of respiratory viruses (influenza, adenoviruses) and pneumonia Mycoplasma contributed to an increase in a period of an infective process. The utmost decrease in indices of cellular immunity (natural killer cell activity, T-cell and phagocytosis function) was detected in a group of patients with a prolonged (over 4 months) virus persistence.
对53例处于病情缓解期临床阶段的慢性阻塞性支气管炎患者进行了病毒学和免疫学研究。这些患者的特征是支气管黏膜刷检活检标本细胞中存在高比例的活跃病毒感染（43%）、病毒持续存在（25%）以及病毒特异性成分（流感病毒的核糖核蛋白）。呼吸道合胞病毒是最常见的持续存在病毒（11%）。呼吸道病毒（流感病毒、腺病毒）与肺炎支原体的高比例关联（72%）导致感染过程持续时间延长。在病毒持续存在时间较长（超过4个月）的患者组中，检测到细胞免疫指标（自然杀伤细胞活性、T细胞和吞噬功能）极度下降。
