Kubesch P, Wehsling M, Tümmler B
Zentrum Biochemie II, Medizinische Hochschule Hannover, Federal Republic of Germany.
Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Jun;265(1-2):197-202. doi: 10.1016/s0176-6724(87)80166-9.
The outer membrane-disorganizing agent polymyxin B nonapeptide sensitized Pseudomonas aeruginosa strains 2-40fold to ciprofloxacin, norfloxacin, and ofloxacin, and 80-200fold to nalidixic acid. Sensitized P. aeruginosa strains were nearly as susceptible to nalidixic acid as Escherichia coli strains. The data suggest that the outer membrane permeability is of critical importance for the antipseudomonal activity of 4-quinolones. The low penetration of the outer membrane is the major cause of the nalidixic acid resistance of P. aeruginosa.
外膜破坏剂多粘菌素B九肽使铜绿假单胞菌菌株对环丙沙星、诺氟沙星和氧氟沙星敏感2 - 40倍，对萘啶酸敏感80 - 200倍。致敏的铜绿假单胞菌菌株对萘啶酸的敏感性与大肠杆菌菌株几乎相同。数据表明，外膜通透性对于4 - 喹诺酮类药物的抗铜绿假单胞菌活性至关重要。外膜通透性低是铜绿假单胞菌对萘啶酸耐药的主要原因。
