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C57BL/6小鼠对3-甲基胆蒽诱导的纤维肉瘤的免疫:通过过继肿瘤中和试验进行体内分析。

Immunity to a 3-methylcholanthrene-induced fibrosarcoma in the C57BL/6 mouse: in vivo analysis by the adoptive tumor neutralization test.

作者信息

Poupon M F, Lespinats G, Kolb J P, Payelle B

出版信息

J Natl Cancer Inst. 1979 Apr;62(4):989-94.

PMID:311871
Abstract

Analyses of the adoptive tumor neutralization test (modified Winn test) in C57BL/6 mice made immune to a 3-methylcholantheene-induced fibrosarcoma showed that the reaction was mediated by a thymus-derived lymphocyte, it was tumor-specific, and the resistance of the immunized donor mouse to the challenge was strongly correlated with the protection of the recipient mouse. Proliferation of immune cells and close contact between tumor cells and immune T-cells were required. The hypothesis of a participation of the recipient in the reaction was considered because of the lack of adoptive protection of pangenic nude mice.

摘要

对免疫于3-甲基胆蒽诱导的纤维肉瘤的C57BL/6小鼠进行的过继性肿瘤中和试验(改良Winn试验)分析表明,该反应由胸腺来源的淋巴细胞介导,具有肿瘤特异性,免疫供体小鼠对攻击的抵抗力与受体小鼠的保护密切相关。需要免疫细胞的增殖以及肿瘤细胞与免疫T细胞之间的紧密接触。由于泛基因裸鼠缺乏过继性保护,因此考虑了受体参与反应的假说。

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1
Immunity to a 3-methylcholanthrene-induced fibrosarcoma in the C57BL/6 mouse: in vivo analysis by the adoptive tumor neutralization test.C57BL/6小鼠对3-甲基胆蒽诱导的纤维肉瘤的免疫:通过过继肿瘤中和试验进行体内分析。
J Natl Cancer Inst. 1979 Apr;62(4):989-94.
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引用本文的文献

1
Decrease in tumour growth by injections of histamine or serotonin in fibrosarcoma-bearing mice: influence of H1 and H2 histamine receptors.
Br J Cancer. 1982 Jan;45(1):54-60. doi: 10.1038/bjc.1982.7.
2
Suppressor T cells in BCG-treated mice interfere with an in vivo specific antitumoral immune response.卡介苗治疗小鼠中的抑制性T细胞会干扰体内特异性抗肿瘤免疫反应。
Br J Cancer. 1984 Jun;49(6):759-68. doi: 10.1038/bjc.1984.119.
3
Histamine in C3H/W mice carrying spontaneous tumors of the mammary gland.携带乳腺自发性肿瘤的C3H/W小鼠中的组胺。
Agents Actions. 1991 May;33(1-2):192-4. doi: 10.1007/BF01993164.